Skylight Confessions: A Novel - Alice Hoffman

Skylight Confessions: A Novel - Alice Hoffman

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Details
EAN / ISBN-139780316005333, 9783527316373
Höhe24 cm
Produktformgebundene Ausgabe
Seitenanzahl660
HerausgeberBack Bay Books
Erscheinungsdatum 02.01.2008
InhaltsverzeichnisEditors Overview PART 1: TECHNOLOGIES Pre-analytical issues in clinical proteomic studies Protein separation by 2DE Protein separation : liquid chromatography HPLC in protein discovery IEF analysis of peptides for biomarkers analysis Capillary electrophoresis separations for clinical proteomics Quantitative proteomics using nanoLC with high accuracy mass spectrometry Antibody microarrays for protein and glycan detection Biomarker Identification: The Role of Experimental Design, Statistics, and Data Sharing PART 2: CANCER Applications of stable isotope tagging based quantitive proteomics in cancer research 2-D liquid seperations, protein microarrays and mass spectrometry in comprehensive analysis of PTM and biomarker discovery Development and Use of Reversed-Phase Protein Microarrays for Clinical Applications CDK1 and cancer: usefulness of proteomic approaches in assesment of the molecular mechanisms and efficacy of novel therapeutics PART 3: CARDIOVASCULAR DISEASE Diagnostic markers for monitoring heart transplant rejection The study of microheterogeneity in human plasma proteins: applications to acute myocardial infarction Discovery of biomarkers for cardiovascular diseases Development of biomarker Developfment Pipeline: Search for Myocardial Ischemia Biomarkers Albuminome as a tool for biomarker discovery PART 4: VASCULAR DISEASES Application of Metabolomics to Cardiovascular Biomarker and Pathway Discovery Urinary biomarkers in diabetic nephropathy and other glomerular diseases Pulmonary proteomics Proteomics providing insights into major psychiatric disorders PART 6: BIOMARKERS Redox Proteomics Analysis of Oxidative Modified Brain Proteins in Alzheimer´s Disease and Mild Cognitive Impairment: Insights into the Progression of This Dementing Disorder Toxicoproteomics: correlating tissue and serum proteins in liver injuries Biomarkers for renal disease and uraemic toxins HIV and other viral screens PART 6: AUTOANTIBODIES AND SIGNATURE BIOMARKERS Application of Fungal Cyclic Peptides and Metabolites Microarray approaches to autoantibody profiling Identification of tumor antigen-directed autoantibodies PART 7: FUTURE Antibody and Reverse Capture Protein Microarrays Use of Antibody Microarrays in the Analysis of Inflammation, Autoimmunity, Viral Infection, and Cancer Metastases The Future: Translation from Discovery to the Clinic - Roles of HUPO and industry in biomarker discovery
HauptbeschreibungUnparalleled in its scope and depth, this book brings together proteomic approaches in diagnosis and treatment from all clinical fields, including clinical toxicology. The result is a new discipline in molecular medicine that will revolutionize the treatment and prevention of cancer, stroke and other severe diseases. Following an overview of clinical proteomics, the authors look at the technologies available, before moving on to cancer, cardiopulmonary disease, diabetes and stroke. A whole section is devoted to toxicity and the work is rounded off with a discussion of the future of clinical proteomics.
Breite17 cm
SpracheEnglisch

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