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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Zoologie Neuronal Acetylcholine Receptors
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Neuronal Acetylcholine Receptors
V.I. Skok, A.A. Selyanko, V.A. Derkach (Taschenbuch, Englisch)
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Beschreibung
Among the different types of receptors for neurotransmitters, nicotinic acetyl choline receptors were the first to be studied systematically; at present they are very well characterized. This is due to the discovery of two very convenient objects that are endowed with nicotinic acetylcholine receptors - the skeletal muscle and the electric organ. The large size of skeletal muscle fibers, which… simplifies the intra cellular recording of transmembrane potentials and currents, played a crucial role in obtaining the fIrst quantitative estimates of the activity of acetylcholine receptors and the kinetics of their interaction with ligands. On the other hand, the extremely high content of receptor protein in the electric organ tissue - two orders higher than in muscle tissue - rendered it highly suitable for studying the biochemistry of recep tors. The combination of pharmacological, electrophysiological, and biochemical approaches resulted in rapid progress in the investigation of acetylcholine receptors. Nicotinic acetylcholine receptors are also present in the neurons of autonomic ganglia, in the central nervous system of vertebrates, and in the ganglion neurons of invertebrates. Although each of these three types of receptors has its own pharma cological specificity, some of their properties are common and differ from those in the acetylcholine receptors of skeletal muscle and electric organ. One of these differences is that neuronal nicotinic receptors usually coexist in the same nerve cell with other receptors, e. g. , muscarinic, serotoninergic, or peptidergic. 106,99 €
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Technische Daten
Erscheinungsdatum
22.03.2012
Sprache
Englisch
EAN
9781468416701, 9781468416701
Herausgeber
Springer US
Sonderedition
Nein
Autor
V.I. Skok, A.A. Selyanko, V.A. Derkach
Seitenanzahl
332
Einbandart
Taschenbuch
Thema-Inhalt
PSV - Zoologie und Tierwissenschaften
PHVN - Biophysik
PSAN - Neurowissenschaften
Höhe
244 mm
Breite
17 cm
Transparenz & Sicherheit
Hersteller: Springer Nature Customer Service Center GmbH, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com
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