The Epigenetics of Autoimmune Diseases

07.04.2009

Englisch

9780470758618, 9780470758618

John Wiley & Sons

Nein

472

1

Gebundene Ausgabe

Immunologie, Genetik

Contributors. PART I: TRANSCRIPTION FACTORS: PARTNERS OF IMMUNE TOLERANCE TO SELF. 1. Transcriptional Regulation of T Cell Tolerance (Brian T. Abe, Ayana Jordan, Vanessa M. Hubbard and Fernando Macian). References. 2. Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells (Julia K. Polansky, Stefan Floess, Jennifer Freyer, Alf Hamann and Jochen Huehn). References. 3. The Role of NF-8B in Central Tolerance (Mingzhao Zhu, Matthew Ruddy and Yang-Xin Fu). References. 4. The Role of Act1 in the Control of Autoimmunity (Trine N. Jörgensen, Natalia V. Giltiay, Angela Johnson and Xiaoxia Li). References. 5. Regulation of T Cell Anergy and Escape from Regulatory T Cell Suppression by Cbl-b (Stefanie Loeser and Josef M. Penninger). References. 6. Indoleamine 2,3-dioxygenase: Transcriptional Regulation and Autoimmunity (Maria Laura Belladonna, Ciriana Orabona, Claudia Volpi, Ursula Grohmann, Paolo Puccetti and Maria Cristina Fioretti). References. PART II: STRESS RESPONSES THAT BREAK IMMUNE SILENCE. 7. Chromatin Modifications, Oxidative Stress and Nucleosome Autoantibodies (Annika Erbacher and Patrice Decker). References. 8. Stress, Epigenetics and Thyroid Autoimmunity (Agathocles Tsatsoulis). References. 9. Reactive Intermediates, Inflammation and Epigenetics in Lupus (Gary S. Gilkeson and Jim C. Oates). References. 10. Post-translational Modification of HMGB1 and Its Role in Immune Activation (Anirudh J. Ullal and David S. Pisetsky). References. 11. Idiosyncratic Drug-Induced Liver Injury: Facts and Perspectives (Jos,. V. Castell and Isabel Miñana). References. PART III: EPIGENETIC MODIFIERS OF AUTOIMMUNITY. 12 Epigenetic Modifications Associated with T Cell Tolerance (Andrew D. Wells and Rajan M. Thomas). References. 13. DNA Methylation Alterations in Systemic Lupus Erythematosus (Biola M. Javierre, Manel Esteller and Esteban Ballestar). References. 14 Long-Range Histone Acetylation Patterns in the Development of Autoimmunity (Thomas M. Aune, Shaojing Chang and Weisong Zhou). References. 15. Roquin Defects Reveal a Role for the microRNA Machinery in Regulating Autoimmunity (Di Yu and Carola G. Vinuesa). References. 16. Autoimmune Response to Post-translationally Modified (Citrullinated) Proteins: Prime Suspect in the Pathophysiology of Rheumatoid Arthritis (Mireille Sebbag, Cyril Clavel, Leonor Nogueira, Jacques Arnaud and Guy Serre). References. 17. Hormones: Epigenetic Contributors to Gender-Biased Autoimmunity (Virginia Rider and Nabih I. Abdou). References. 18. Epigenetics and Systemic Sclerosis (Serena Guiducci and Marco Matucci Cerinic). References. 19. Epigenetic Regulation of B Lymphocyte Development and Repertoire Selection: Relevance to Autoimmunity (Moncef Zouali). References. PART IV: TOWARDS NOVEL EPIGENETIC-BASED IMMUNO-INTERVENTION STRATEGIES IN AUTOIMMUNE DISEASE. 20. Protective Effects of Epigenetic Modifications in Experimental Inflammatory Bowel Disease (Rainer Glauben, Elena Sonnenberg and Britta Siegmund). References. 21. Epigenetic Regulation of Autoimmune Diseases through Deacetylase Inhibition (Bin Li, Yuan Shen, Zhaocai Zhou, Xiaomin Song, Kathryn Bembas, Xiao Yun Zhao, Zheng Cai, Alan Berezov, Sandra J. Saouaf, Hongtao Zhang, Qiang Wang and Mark I. Greene). References. 22. Histone Deacetylases and Autoimmunity (András Treszl, GergQ Mészáros, Gergely Toldi and Barna Vásárhelyi). References. 23. Histone Deacetylase Inhibitors as a Therapeutic Modality in Multiple Sclerosis (Steven G. Gray). References. Index.

244 mm

16.8 cm