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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Biochemie & Biophysik Physics at the Biomolecular Interface
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Physics at the Biomolecular Interface
Ariel Fernández (Gebundene Ausgabe, Englisch)
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Beschreibung
This book focuses primarily on the role of interfacial forces in understanding biological phenomena at the molecular scale. By providing a suitable statistical mechanical apparatus to handle the biomolecular interface, the book becomes uniquely positioned to address core problems in molecular biophysics. It highlights the importance of interfacial tension in delineating a solution to the protein… folding problem, in unravelling the physico-chemical basis of enzyme catalysis and protein associations, and in rationally designing molecular targeted therapies. Thus grounded in fundamental science, the book develops a powerful technological platform for drug discovery, while it is set to inspire scientists at any level in their careers determined to address the major challenges in molecular biophysics. The acknowledgment of how exquisitely the structure and dynamics of proteins and their aqueous environment are related attests to the overdue recognition that biomolecular phenomena cannot be effectively understood without dealing with interfacial behaviour. There is an urge to grasp how biologically relevant behaviour is shaped by the structuring of biomolecular interfaces and how interfacial tension affects the molecular events that take place in the cell. This book squarely addresses these needs from a physicist perspective. The book may serve as a monograph for practitioners and, alternatively, as an advanced textbook. Fruitful reading requires a background in physical chemistry and some basics in biophysics. The selected problems at the end of the chapters and the progression in conceptual difficulty make it a suitable textbook for a graduate level course or an elective course for seniors majoring in chemistry, physics, biomedical engineering or related disciplines. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
22.07.2016
Sprache
Englisch
EAN
9783319308517
Herausgeber
Springer International Publishing
Serien- oder Bandtitel
Soft and Biological Matter
Sonderedition
Nein
Autor
Ariel Fernández
Seitenanzahl
483
Einbandart
Gebundene Ausgabe
Buch Untertitel
Fundamentals for Molecular Targeted Therapy
Schlagwörter
Interfacial biological water, Nanoscale water dielectrics, Protein-water interface, Solution to the protein folding problem, Protein structural defects, Interfacial tension in biology, Rational drug design, Dehydron-wrapping technologies, Drug specificity filters, Epistructural biology, Protein Structure
Thema-Inhalt
PHVN - Biophysik
PNR - Physikalische Chemie
PNB - Medizinische Chemie, Pharmazeutische Chemie
PSB - Biochemie
MBGR - Medizinische Forschung
GPFC - Kybernetik und Systemtheorie
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer Nature Customer Service Center GmbH, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com
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