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Bücher Wissen & Bildung Englische Bücher Naturwissenschaft, Medizin, Informatik, Technik Biologie Zoologie Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells
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Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells
(Taschenbuch, Englisch)
Optischer Zustand
Beschreibung
This is a book about how Cl- crosses the cell membranes of nerve, muscle, and glial cells. Not so very many years ago, a pamphlet rather than book might have resulted from such an endeavor! One might ask why Cl-, the most abundant biological anion, attracted so little attention from investigators. The main reason was that the prevailing paradigm for cellular ion homeostasis in the 1950s and 1960s… assigned Cl- a ther modynamically passive and unspecialized role. This view was particularly prominent among muscle and neuroscience investigators. In searching for reasons for such a negative (no pun intended) viewpoint, it seems to us that it stemmed from two key experimental observations. First, work on frog skeletal muscle showed that Cl- was passively distributed between the cytoplasm and the extracellular fluid. Second, work on Cl- transport in red blood cells confirmed that the Cl- transmembrane distribution was thermodynamically passive and, in addition, showed that Cl- crossed the mem brane extremely rapidly. This latter finding [for a long time interpreted as being the result of a high passive chloride electrical permeability(? CI)] made it quite likely that Cl- would remain at thermodynamic equilibrium. These two observations were gener alized and virtually all cells were thought to have a very high P Cl and a ther modynamically passive Cl- transmembrane distribution. These concepts can still be found in some physiology and neuroscience textbooks. 213,99 €
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Technische Daten
Erscheinungsdatum
27.04.2013
Sprache
Englisch
EAN
9781475796872
Herausgeber
Springer US
Sonderedition
Nein
Seitenanzahl
426
Einbandart
Taschenbuch
Schlagwörter
attention, blood cell, cells, neurons, neuroscience, physiology, skeletal muscle
Thema-Inhalt
PSV - Zoologie und Tierwissenschaften
PHVN - Biophysik
PSAN - Neurowissenschaften
Höhe
254 mm
Breite
17.8 cm
Transparenz & Sicherheit
Hersteller: Springer Nature Customer Service Center GmbH, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com
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