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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Technik Phase Behavior of Pharmaceutical Cocrystals
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Phase Behavior of Pharmaceutical Cocrystals
Linda Lange (Taschenbuch, Englisch)
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Beschreibung
The formation of pharmaceutical cocrystals (CCs) is an emerging method to meet the requirements on solubility and dissolution behavior of active pharmaceutical ingredients (APIs). These CCs are crystalline solids that consist of the API and at least one coformer (CF) in a defined stoichiometry. In industrial scale, CC formation is performed by crystallization from solution, which is often affected… by pH-dependent dissociation, polymorphic transitions, as well as by formation of hydrates and salts. Therefore, the purpose of this work is to increase the efficiency of the CC formation processes by a thermodynamically correct description of the CC phase behavior.
The presented modeling procedure comprises solubility-line calculations of the API, CF, and the CC itself, allowing for the real interactions between solutes and solvents by using the Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT). The CC solubility was modeled applying a solubility product based on the knowledge of only a single experimental solubility data point in any solvent. Using this information, the CC solubility in other solvents and even solvent mixtures was predicted without need of additional data. Furthermore, based on the Gibbs-Helmholtz equation, the model was applied to predict the CC solubility at other temperatures. In aqueous solutions, the increase of solubility by pH change was considered accounting for the dissociation equilibria, whereas the solubilities of hydrates and salts were again calculated by applying solubility products. On top of that, the proposed approach enabled the description of the complex phase behavior of CC systems exhibiting polymorphic transitions.
The modeling results were verified by experimental data. PC-SAFT is shown to be able to correlate and predict solubilities of CCs, hydrates, salts, and polymorphs for all considered CC systems correctly. Thus, the proposed approach allows for a reliable description of the CC phase behavior with a minimal experimental effort, which in turn results in a more efficient CC formation. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
23.01.2017
Sprache
Englisch
EAN
9783843929677
Herausgeber
Dr. Hut
Serien- oder Bandtitel
Thermodynamik
Sonderedition
Nein
Autor
Linda Lange
Seitenanzahl
218
Einbandart
Taschenbuch
Schlagwörter
cocrystals, active pharmaceutical ingredients, Perturbed-Chain Statistical Associating Fluid Theory
Thema-Inhalt
P - Mathematik und Naturwissenschaften
PH - Physik
PHH - Thermodynamik und Wärme
Höhe
210 mm
Breite
14.8 cm
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