Replacing Animal Models

13.04.2012

Englisch

9780470974254

John Wiley & Sons

Nein

214

Gebundene Ausgabe

Fadenbindung

A Practical Guide to Creating and Using Culture-based Biomimetic Alternatives

Biotechnology, Cell & Molecular Biology, Biowissenschaften, Life Sciences, Biomedical Engineering, Biomedizintechnik, Zell- u. Molekularbiologie, Zell-, Gewebe- u. Gen-Engineering, Biotechnologie i. d. Biowissenschaften, Gewebekultur, Biotechnologie, Tissue, Cell, and Genetic Engineering

PS - Biologie, Biowissenschaften

Contributors, vii Preface, xi Section 1 Introductory Material 1 Potential Advantages of Using Biomimetic Alternatives, 3 Jamie Davies 2 Overview of Biomimetic Alternatives, 13 Jamie Davies Section 2 Culture Methods 3 Pancreatic Islets, 23 Eli C Lewis 4 Endometrial Organoid Culture, 35 Merja Blauer 5 Modelling Lymphatic and Blood Capillary Patterning, 45 Francoise Bruyere, Catherine Maillard, Charlotte Erpicum and Agnes Noel 6 Precision-cut Lung Slices (PCLS), 57 Christian Martin and Stefan Uhlig 7 Human Colon Tissue in Organ Culture, 69 Michael K Dame and James Varani 8 Fetal Organ Culture, 81 Jamie Davies 9 Design of a Mechanical Loading Device to Culture Intact Bovine Spinal Motion Segments under Multiaxial Motion, 89 Jochen Walser, Stephen John Ferguson and Benjamin Gantenbein-Ritter 10 Magnetic Assembly of Tissue Surrogates, 107 Chien-Yu Fu and Hwan-You Chang 11 Assembly of Renal Tissues by Cellular Self-organization, 115 Mathieu Unbekandt Section 3 Case Studies of Use 12 Hierarchical Screening of Pathways: Using Cell and Organ Cultures to Reduce use of Transgenic Mice, 125 Guangping Tai and Jamie Davies 13 Lung Organoid Culture to Study Responses to Viruses, 137 Wenxin Wu, J Leland Booth and Jordan P Metcalf 14 Organ-cultured Human Skin for the Study of Epithelial Cell Invasion of Stroma, 151 James Varani 15 Organotypic Mandibular Cultures for the Study of Inflammatory Bone Pathology, 159 Alastair J Sloan, Sarah Y Taylor and Emma L Smith 16 Three-dimensional, High-density and Tissue Engineered Culture Models of Articular Cartilage, 167 Ali Mobasheri, Sara Kelly, Abigail L. Clutterbuck, Constanze Buhrmann and Mehdi Shakibaei 17 Concluding Remarks, 193 Jamie Davies Appendix 1 Sources of funding for development of culture-based alternatives, 195 Appendix 2 Databases and web-based discussions relevant to development of alternatives, 197 Index, 199

246 mm

18.9 cm