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Clinical Trial Design
Guosheng Yin (Gebundene Ausgabe, Englisch)
★★★★★
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Beschreibung
A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods
There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis… testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics.
Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include:
* Risk and benefit analysis for toxicity and efficacy trade-offs
* Bayesian predictive probability trial monitoring
* Bayesian adaptive randomization
* Late onset toxicity and response
* Dose finding in drug combination trials
* Targeted therapy designs
The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials.
Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
09.02.2012
Sprache
Englisch
EAN
9780470581711
Herausgeber
John Wiley & Sons
Sonderedition
Nein
Autor
Guosheng Yin
Seitenanzahl
364
Einbandart
Gebundene Ausgabe
Einbandart Details
Fadenbindung
Buch Untertitel
Bayesian and Frequentist Adaptive Methods
Hersteller: Wiley, Boschstrasse 12, Weinheim, Deutschland, 69469, product_safety@wiley.com, Wiley-VCH GmbH
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