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Beschreibung
Metals in Medicine is a textbook directed a senior undergraduates and beginning graduate students, which describes metal-based agents for treating and diagnosing disease. Opening chapters present basic bonding concepts that are applicable to metallo-drugs and their biological targets, interactions that exist between the agents and substances in the biological milieu, basic pharmacokinetic and Dieses Produkt haben wir gerade leider nicht auf Lager.
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Bis zu 50 % günstiger als neu
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Technische Daten
Erscheinungsdatum
13.11.2009
Sprache
Englisch
EAN
9780470681961
Herausgeber
John Wiley & Sons
Sonderedition
Nein
Autor
James C. Dabrowiak
Seitenanzahl
334
Einbandart
Gebundene Ausgabe
Schlagwörter
Drug Discovery & Development, Biochemie u. Chemische Biologie, Chemistry, Chemie, Wirkstoffforschung u. -entwicklung, Biochemistry (Chemical Biology), Bioanorganische Chemie, Arzneimittelentwicklung, Bioinorganic Chemistry, Metall
Thema-Inhalt
PNK - Anorganische Chemie
Inhaltsverzeichnis
Chapter 1. Inorganic Chemistry Basics
1.1 Crystal field theory
1.2 Molecular orbital theory
1.3 Absorption spectra of metal complexes
1.4 Magnetic properties of metal complexes
1.5 Reactions of metal complexes
1.6 Bibliography
1.7 References
1.8 Problems
Chapter 2. Metallo-Drugs and Their Action
2.1 Introduction
2.2 Proteins as Targets for Metallo-Drugs
2.3 DNA as a target for Metallo-Drugs
2.4 Reactions of Metal Complexes in the Biological Milieu.
2.5 Evaluating the Pharmacological Effects of Agents
2.6 From Discovery to the Marketplace and Beyond
2.7 Bibliography
2.8 References
2.9 Problems
Chapter 3. Cisplatin
3.1 Physical and Chemical Properties of Cisplatin
3.2 Formulation, Administration, and Pharmacokinetics
3.3 Reaction of Cisplatin in Biological Media
3.4 Uptake, Cytotoxicity, and Resistance
3.5 Interaction of Cisplatin with Cellular Targets
3.6 Bibliography
3.7 References
3.8 Problems
Chapter 4. Platinum Anticancer Drugs
4.1 Carboplatin
4.2 Oxaliplatin
4.3 New Platinum Agents
4.4 Bibliography
4.5 References
4.6 Problems
Chapter 5. Ruthenium, Titanium, and Gallium for Treating Cancer
5.1 Ruthenium for Treating Cancer
5.2 Titanium Compound for Treating Cancer.
5.3 Gallium for Treating Cancer.
5.4 Bibliography
5.5 References
5.6 Problems
Chapter 6. Gold Compounds for Treating Arthritis, Cancer, and Other Diseases
6.1 Chemistry of Gold in Biological Media
6.2 Gold Complexes for Treating Cancer
6.3 Gold Complexes for Treating AIDS and Other Diseases
6.4 Bibliography
6.5 References
6.6 Problems
Chapter 7. Vanadium, Copper, and Zinc in Medicine
7.1 Vanadium for Treating Diabetes
7.2 Copper and Alzheimer's Disease.
7.3 Copper in Wilson's and Menkes Diseases.
7.4 Zinc-Bicyclam. A Cytokine Receptor Antagonist
7.5 Bibliography
7.6 References
7.7 Problems
Chapter 8. Metal Complexes for Diagnosing Disease.
8.1 Technetium-99m in diagnostic nuclear medicine.
8.2 Metal compounds as contrast agents for MRI.
8.3 Radionuclides for palliative care and cancer treatment.
8.4 Bibliography
8.5 References
8.6 Problems.
Chapter 9. Nanomedicine
9.1 Nanoscience in Treating Disease
9.2 Nanoscience in Diagnosing Disease
9.3 Potential Health Risks of Nanoparticles
9.4 Sources
9.5 Literature Cited
9.6 Problems
Index
Höhe
255 mm
Breite
19.7 cm
-.-
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