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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Chemie Physikalische Chemie Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products
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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products
Taro Noguchi (Gebundene Ausgabe, Englisch)
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Beschreibung
This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are… mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested o nly natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an α-tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
16.11.2017
Sprache
Englisch
EAN
9789811066221
Herausgeber
Springer Singapore
Serien- oder Bandtitel
Springer Theses
Sonderedition
Nein
Autor
Taro Noguchi
Seitenanzahl
80
Auflage
1st edition 2018
Einbandart
Gebundene Ausgabe
Schlagwörter
Mirror-Image Protein Technology, Total Synthesis of Natural Products, Total Synthesis of Proteins, Natural Product-based Drug Discovery, Anticancer Agents
Thema-Inhalt
PNB - Medizinische Chemie, Pharmazeutische Chemie
PNN - Organische Chemie
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer Nature Customer Service Center GmbH, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com
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