Flash Chemistry

26.09.2008

Englisch

9780470035863

John Wiley & Sons

Nein

Jun-ichi Yoshida

244

Gebundene Ausgabe

Fast Organic Synthesis in Microsystems

Chemie, Chemistry, Industrial Chemistry, Katalyse, Methods - Synthesis & Techniques, Organic Chemistry, Organische Chemie, Organische Chemie / Methoden, Synthesen, Verfahren, Physical Organic Chemistry, Physikalische Organische Chemie, Technische u. Industrielle Chemie

PNN - Organische Chemie

1. Introduction. 1.1 Flask chemistry. 1.2 Flash chemistry. 1.3 Flask chemistry or flash chemistry. 2. The Background to Flash Chemistry. 2.1 How do chemical reactions take place?. 3. What is Flash Chemistry?. 4. Why is Flash Chemistry Needed?. 4.1 Chemical reaction, an extremely fast process at molecular level. 4.2 Rapid construction of chemical libraries. 4.3 Rapid synthesis of radioactive PET probes. 4.4 On-demand rapid synthesis in industry. 4.5 Conclusions. 5. Methods of Activating Molecules. 5.1 Thermal activation of organic molecules. 5.2 Photochemical activation. 5.3 Electrochemical activation. 5.4 Chemical activation. 5.5 Accumulation of reactive species. 5.6 Continuous generation of reactive species in a flow system. 5.7 Interconversion between reactive species. 5.8 Conclusions. 6. Methods of Activating Molecules. 6.1 Mixing. 6.2 Temperature control. 6.3 Residence time control. 6.4 Conclusions. 7. Microfluidic Devices and Microflow Systems. 7.1 Brief history. 7.2 Characteristic features of microflow systems. 7.3 Microstructured fluidic devices. 7.4 Conclusions. 8. Applications of Flash Chemistry in Organic Synthesis. 8.1 Highly exothermic reactions which are difficult to control in macrobatch reactors. 8.2 Reactions in which a reactive intermediate easily decomposes in macrobatch reactors. 8.3 Reactions the products of which easily decompose in macrobatch reactors. 8.4 Reactions in which undesired byproducts are produced in the subsequent reactions in macrobatch reactors. 8.5 Reactions that can be accelerated using microflow systems. 8.6 Summary. 9. Polymer Synthesis Based on Flash Chemistry. 9.1 Introduction. 9.2 Chain-growth polymerization and step-growth polymerization. 9.3 Molecular weight and molecular-weight distribution. 9.4 Cationic polymerization. 9.5 Free-radical polymerization. 9.6 Summary. 10. Industrial Applications of Flash Chemistry. 10.1 Synthesis of diarylethene as photochromic compound (micrometer size single reactor). 10.2 Synthesis of pharmaceutically interesting spiro lactone fragment of nueropeptide Y (Millimeter size single reactor). 10.3 Grignard Exchange Process (Internal numbering-up). 10.4 Radical Polymerization Process (Numbering-up). 10.5 Other examples of industrial applications of flash chemistry . 10.6 Flash chemistry as a powerful way of sustainable chemical synthesis. 11. Outlook of Flash Chemistry.

237 mm

16.7 cm