The T-Cell Receptors

31.05.1988

Englisch

9780306427084

Springer US

Nein

235

1988

Gebundene Ausgabe

leukemia, parasite, histocompatibility, evolution, proteins, transcription, lymphocytes, Thymus, pathology, immunoglobulin, T cell, growth, Antigen

MJCM - Immunologie PSV - Zoologie und Tierwissenschaften PST - Botanik und Pflanzenwissenschaften

1 Introduction.- 2 The ? and ? Chains of the T-Cell Receptor.- 1. Introduction.- 2. The Genomic Structure of the T-Cell Receptor Genes.- 2.1. ?-Chain genes.- 2.2. ?-Chain genes.- 3. Rearrangement of T-Cell Receptor Genes.- 3.1. T-Cell Receptor Recombinational Signals.- 3.2. ?-Chain Rearrangement and Expression.- 3.3. ? Rearrangement in T-Cell Subsets.- 3.4. ?-Chain Transcripts.- 3.5. ?-Chain Rearrangement and Transcription.- 4. The Generation of T-Cell Receptor Diversity.- 5. The T-Cell Receptor Repertoire.- 6. T-Cell Receptor Diversity.- 7. Conclusion.- References.- 3 Immunoglobulin-Related Structures Associated with Vertebrate Cell Surfaces.- 1. Members of the Ig Superfamily.- 2. Igs and the Domain Hypothesis.- 3. Statistical Significance of the Similarities to Ig.- 4. Categories of Molecules in the Ig Superfamily.- 4.1. Antigen Receptors and Associated Molecules.- 4.2. MHC Antigens.- 4.3. Antigens Associated with ?2 Microglobulin.- 4.4. Receptors for Ig.- 4.5. T-Lymphocyte Marker Antigens.- 4.6. Brain/Thymus Antigens.- 4.7. Neural Cell-Surface Molecules.- 4.8. Growth Factor Receptors.- 4.9. Molecules Not Known To Be Cell-Surface Associated.- 5. Gene Organization.- 6. Evolution of Structural Types in the Ig Superfamily.- 7. Possible Functional Derivation of the Ig Superfamily.- References.- 4 T-Cell Receptor Genes: Mutant Mice and Genes.- 1. Introduction.- 2. TcR ?-Chain Locus.- 3. Deletion Type Mutants.- 3.1. V? Mutants.- 3.2. C?-Deletion Mutant.- 3.3. V?-C?-Deletion Mutants.- 4. Nondeletion Mutants.- 4.1. V? Genes.- 4.2. V? Genes.- 4.3. V? Genes.- References.- 5 Thymic Ontogeny and the T-Cell Receptor Genes.- 1. Thymic Ontogeny.- 2. The T-Cell Receptor and Thymic Ontogeny.- 3. Thymic Leukemias.- 4. Conclusions.- References.- 6 The T-Cell Receptor/T3 Complex on the Surface of Human and Murine T Lymphocytes.- 1. T-Cell Receptors for Antigen.- 2. Antigen Recognition by T-Cell Receptors after the Establishment of Cell-Cell Interactions.- 3. The T Cell Receptor-T3 Structure.- 3.1. Description of the T3 Antigen and Its Relationship to the T-Cell Receptor.- 3.2. The Murine T-Cell Receptor-T3 Complex.- 3.3. The T3-? Chain.- 3.4. The Amino Acid Sequence of T3-? Derived from the cDNA Nucleotide Sequence.- 3.5. Physical Association of the T-Cell Receptor and T3 Proteins.- 3.6. Coordinate Cell-Surface Expression of the T-Cell Receptor-T3 Complex.- 4. Organization of the Genes Encoding the T3 Proteins.- 4.1. The T3-? Gene.- 4.2. The T3-? Gene.- 4.3. Chromosomal Locations of T3-? and -? Genes.- 5. Expression of the T3-Genes during Intrathymic Differentiation.- References.- 7 Role of the T3/T-Cell Antigen Receptor Complex in T-Cell Activation.- 1. Introduction.- 2. The T3/Ti Complex.- 3. The T3/Ti Antibodies Provide One Stimulus Required for Human T-Cell Activation.- 4. T3/Ti-Induced Hydrolysis of Polyphosphoinositides and Increase in the Concentration of Cytoplasmic Free Calcium.- 5. T-Cell Activation Induced by Soluble or Immobilized T3 MAb.- 6. The Role of Activation of Protein Kinase C for the Activation of Resting T Lymphocytes.- 7. Summary.- References.- 8 The Structure and Expression of the T-Cell ?-, ?-, and ?-Chain Genes in Human Malignancies.- 1. Introduction.- 2. T-Cell Malignancies.- 3. Technical Considerations.- 3.1. Analysis of ? Chain.- 3.2. Analysis of ? Chain.- 3.3. Analysis of ?-Chain Structure and Expression.- 4. Rearrangement and Expression of the TcR Genes in Human Neoplasias and Related Disorders.- 5. T-Cell Malignancies.- 5.1. Acute T-Lymphoid Neoplasms.- 5.2. Chronic T-Cell Malignancies.- 5.3. T8 Lymphocytosis.- 5.4. T-Cell Lymphomas.- 5.5. Non-B Non-T All.- 5.6. B-CLL.- 5.7. Lymphoproliferative Disorders of Uncertain Origin.- 5.8. Another Hematopoietic Malignancy.- 6. Observations.- 7. T-Cell Ontogeny.- 7.1. Lymphoid Malignancies with Rearrangement of Both TcR and Ig Genes.- 7.2. T-Cell Malignancies with More than Two Rearranged Bands.- 7.3. Involvement of TcR Genes in Chromosome Translocations.- 8. Conclusion.- References.- 9 The Involvement of the T-Cell Receptor in Chromosomal Aberrations.- 1. The Involvement of the T-Cell Receptor in Chromosomal Aberrations.- 2. The Burkitt’s Lymphoma Model.- 3. What is the Mechanism of Translocation in Burkitt’s Lymphoma and Other B-Lymphocyte Tumors?.- 4. The Chromosomal Locations of the T-Cell Receptor ?, ?, and ? Chains—Relevance to Chromosomal Aberrations That Highlight Regions of Genomic Activity in Differentiated Cells.- 5. Cloning Studies of Chromosomal Aberrations in T Cells.- 6. The Relevance of the Involvement of the T-Cell Receptor Genes in Chromosomal Aberrations of T Cells.- 7. Summary.- References.- 10 MHC-Disease Associations and T-Cell-Mediated Immunopathology.- 1. Introduction.- 2. Proposal.- 3. Host-Parasite Relationship: General Parameters.- 4. Supporting Evidence.- References.- 11 The ?-? Heterodimer: A Second T-Cell Receptor?.- 1. Cloning of the ? Chain.- 2. Genomic Organization of the ?-Chain Loci in Mouse and Man.- 2.1. The Murine ?-Chain Genes.- 2.2. The Human ?-Chain Genes.- 3. ?-Chain Expression.- 4. ?? as a Possible Second T-Cell Receptor.- 5. Possible Function of the ? Receptor.- 6. Conclusion.- References.

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