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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Biochemie & Biophysik Targeting the Broadly Pathogenic Kynurenine Pathway
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Targeting the Broadly Pathogenic Kynurenine Pathway
(Taschenbuch, Englisch)
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Beschreibung
Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted… therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
23.08.2016
Sprache
Englisch
EAN
9783319363219
Herausgeber
Springer International Publishing
Sonderedition
Nein
Seitenanzahl
430
Auflage
Softcover reprint of the original 1st edition 2015
Einbandart
Taschenbuch
Schlagwörter
Indoleamine-2,3-dioxygenase, Inflammation and cardiovascular disease, Kynurenine pathway, Tryptophan metabolism, neurodegenerative diseases, tryptophan-2,3-dioxygenase, Protein Structure
Thema-Inhalt
PSE - Chemische Biologie
PSB - Biochemie
MBGR - Medizinische Forschung
PSF - Zellbiologie (Zytologie)
PSAN - Neurowissenschaften
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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