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Beschreibung
This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis,… derivatization and QSAR analysis. Taxonomic and chemotaxonomic aspects related to the Asteraceae family are also contributed. The book begins by describing the chemical characteristics of STLs, their classification in different skeleton types, synthesis, distribution in nature and their most important biological properties. An overview of the group's main representatives, based on their importance for human health, as well as an update of the most recently isolated STLs, follow. The authors also provide an overview of the most common methods described in the literature for the extraction, purification, identification and structure elucidation of STLs, while also highlighting more recently developed methods. Furthermore, experts in the field provide an in-depth discussion of the most commonly employed in vitro and in vivo antiprotozoal assays against the different stages of parasites, as well as STLs' properties as anticancer agents in numerous cancer cell lines and animal models. Lastly, the book presents examples of the in vitro and in vivo activity of STLs and their mechanism of antiprotozoal action, together with an analysis of ultrastructural alterations, observed using TEM techniques. The book is aimed at scientists working on natural products: both those investigating this particular group of compounds and those who wish to further explore its potential as new drugs for medical conditions such as protozoal diseases and cancer. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
20.06.2018
Sprache
Englisch
EAN
9783319782737
Herausgeber
Springer International Publishing
Sonderedition
Nein
Seitenanzahl
371
Auflage
1st edition 2018
Einbandart
Gebundene Ausgabe
Buch Untertitel
Advances in their Chemistry and Biological Aspects
Schlagwörter
chemistry of sesquiterpene lactones, pharmacology of sesquiterpene lactones, antiprotozoal activity of sesquiterpene lactones, antiproliferative activity of sesquiterpene lactones, SAR studies of sesquiterpene lactones, synthesis of sesquiterpene lactones, sesquiterpene lactones synthetic derivatives, isolation of sesquiterpene lactones, characterization of sesquiterpene lactones
Thema-Inhalt
PNB - Medizinische Chemie, Pharmazeutische Chemie
MKG - Pharmakologie
PNN - Organische Chemie
PSB - Biochemie
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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