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Beschreibung
Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and… gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host suggests that MC are among the first cells to initiate defensive mechanisms. MC have long been recognized as key cells of type I hypersensitivity reactions. Several lines of evidence, however, indicate that they not only express critical effector functions in classic IgE-associated allergic disorders, but also play important roles in host defense against parasites, bacteria and perhaps even viruses. Indeed, it is now clear that MC can contribute to host defense in thecontext of either acquired or innate immune responses through the release of a myriad of pro-inflammatory and immunoregulatory molecules and the expression of a wide spectrum of surface receptors for cytokines and chemokines. Moreover, there is growing evidence that MC exert distinct non-immunological functions, playing a relevant role in tissue homeostasis, remodeling and fibrosis as well as in the processes of tissue angiogenesis. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
30.07.2019
Sprache
Englisch
EAN
9783030241896
Herausgeber
Springer International Publishing
Sonderedition
Nein
Autor
Domenico Ribatti
Seitenanzahl
112
Auflage
1st edition 2019
Einbandart
Gebundene Ausgabe
Buch Untertitel
A Multifunctional Effector Cell
Schlagwörter
Angiogenesis, Basophils, Mast cell, Tumor growth, Vascultitides
Thema-Inhalt
MJCL - Onkologie
MJCM - Immunologie
MFN - Genetik, Medizin
MBGR - Medizinische Forschung
PSF - Zellbiologie (Zytologie)
MB - Medizin, allgemein
Höhe
235 mm
Breite
15.5 cm
Transparenz & Sicherheit
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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