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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Biochemie & Biophysik Cancer Drug Delivery Systems Based on the Tumor Microenvironment
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Cancer Drug Delivery Systems Based on the Tumor Microenvironment
(Gebundene Ausgabe, Englisch)
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Beschreibung
This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been… numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
30.01.2020
Sprache
Englisch
EAN
9784431568780
Herausgeber
Springer Tokyo
Sonderedition
Nein
Seitenanzahl
325
Auflage
1st edition 2019
Einbandart
Gebundene Ausgabe
Schlagwörter
Anticancer Agents, Cancer Biology, Cancer Therapy, Cancer pathphysiology, Nanobiotechonology
Thema-Inhalt
PNB - Medizinische Chemie, Pharmazeutische Chemie
MJCL - Onkologie
PHFC - Physik der kondensierten Materie (Flüssigkeits- und Festkörperphysik)
PDT - Nanowissenschaften
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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