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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Medizin Nichtklinische Fächer Estrogen Receptor and Breast Cancer
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Beschreibung
The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies… against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics. 181,89 €
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Technische Daten
Erscheinungsdatum
21.12.2018
Sprache
Englisch
EAN
9783030075934
Herausgeber
Springer International Publishing
Serien- oder Bandtitel
Cancer Drug Discovery and Development
Sonderedition
Nein
Seitenanzahl
417
Auflage
Softcover reprint of the original 1st edition 2019
Einbandart
Taschenbuch
Buch Untertitel
Celebrating the 60th Anniversary of the Discovery of ER
Schlagwörter
estrogen receptor, breast cancer, targeted therapies against ER pathways, Tamoxifen, molecular functions of ER
Thema-Inhalt
MJCL - Onkologie
MBGR - Medizinische Forschung
Höhe
235 mm
Breite
15.5 cm
Transparenz & Sicherheit
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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