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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Biochemie & Biophysik Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems
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Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems
(Taschenbuch, Englisch)
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Beschreibung
Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd “living fossil” ( Limulus ). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma).… Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of “ at will ” production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated. Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
15.08.2020
Sprache
Englisch
Originalsprache
Englisch
EAN
9783030171506
Herausgeber
Springer International Publishing
Sonderedition
Nein
Seitenanzahl
869
Auflage
1st edition 2019
Einbandart
Taschenbuch
Autorenporträt
Kevin Williams graduated from Texas A&M in 1982 with a BS in Microbiology. From there spent 30 years at Eli Lilly in Indianapolis. After retirement he has been at Hospira, Lonza, GE, and now BioMerieux .
Schlagwörter
endotoxin, lipopolysaccharides, pharmaceutical contaminants, Pyrogen, adjuvant, limulus, LAL (Limulus amebocyte lysate), depyrogenation, fever, immunogenicity
Thema-Inhalt
PNB - Medizinische Chemie, Pharmazeutische Chemie
MKFM - Mikrobiologie und Virologie
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer Nature Customer Service Center GmbH, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com
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