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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Medizin Nichtklinische Fächer Principles of Cancer Treatment and Anticancer Drug Development
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Principles of Cancer Treatment and Anticancer Drug Development
Wolfgang Link (Taschenbuch, Englisch)
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Beschreibung
This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the… mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND)and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
20.09.2020
Sprache
Englisch
EAN
9783030187248
Herausgeber
Springer International Publishing
Sonderedition
Nein
Autor
Wolfgang Link
Seitenanzahl
145
Auflage
1st edition 2019
Einbandart
Taschenbuch
Autorenporträt
Dr. Wolfgang Link is an Assistant Professor at the Universisty of Algarve in the Department of Biomedical Sciences and Medicine. He is also Head of Oncobiology at the Center for Biomedical Research (CBMR).
Schlagwörter
drug discovery, preclinical drug development, targeted therapy, chemotherapy, clinical trials, antibacterial drug resistance
Thema-Inhalt
MJCL - Onkologie
MBGR - Medizinische Forschung
PNB - Medizinische Chemie, Pharmazeutische Chemie
TCB - Biotechnologie
MKFM - Mikrobiologie und Virologie
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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