iPhoneAlle anzeigen
iPhone 11iPhone 11 ProiPhone 11 Pro MaxiPhone 12iPhone 12 ProiPhone 12 Pro MaxiPhone 12 miniiPhone 13iPhone 13 ProiPhone 13 Pro MaxiPhone 13 miniiPhone 14iPhone 14 PlusiPhone 14 ProiPhone 14 Pro MaxiPhone 15iPhone 15 PlusiPhone 15 ProiPhone 15 Pro MaxiPhone 16iPhone 16 PlusiPhone 16 ProiPhone 16 Pro MaxiPhone 16eiPhone 8iPhone 8 PlusiPhone SE 2020iPhone SE 2022iPhone XiPhone XRiPhone XSiPhone XS Max
Galaxy A-SerieAlle anzeigen
Galaxy A12Galaxy A13Galaxy A13 5GGalaxy A14Galaxy A15Galaxy A16Galaxy A17 5GGalaxy A20eGalaxy A21Galaxy A22Galaxy A23Galaxy A24Galaxy A25Galaxy A26 5GGalaxy A32Galaxy A33Galaxy A34Galaxy A35Galaxy A36 5GGalaxy A40Galaxy A41Galaxy A42Galaxy A50Galaxy A51Galaxy A52Galaxy A53Galaxy A54Galaxy A55Galaxy A56 5GGalaxy A70Galaxy A71Galaxy A72
Redmi SeriesAlle anzeigen
Redmi 10Redmi 13CRedmi 15 5GRedmi Note 10Redmi Note 10 ProRedmi Note 11Redmi Note 11 ProRedmi Note 11 Pro Plus 5GRedmi Note 11sRedmi Note 12Redmi Note 12 5GRedmi Note 12 ProRedmi Note 12 Pro 5GRedmi Note 12 Pro PlusRedmi Note 13Redmi Note 13 5GRedmi Note 13 ProRedmi Note 13 Pro PlusRedmi Note 14Redmi Note 14 Pro PlusRedmi Note 8Redmi Note 8 ProRedmi Note 9Redmi Note 9 Pro
- Startseite
Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Chemie Organische Chemie Synthesis of Marine Steroids with Unusual Ring Systems: Eurysterol A and DELTA24-Dihydro-6-epi-Monanchosterol A and Total Synthesis of Houttuynoid B-Derivatives as Potential Antiviral Agents
Derzeit nicht verfügbar
Handgeprüfte Gebrauchtware
Bis zu 50 % günstiger als neu
Der Umwelt zuliebe
Synthesis of Marine Steroids with Unusual Ring Systems: Eurysterol A and DELTA24-Dihydro-6-epi-Monanchosterol A and Total Synthesis of Houttuynoid B-Derivatives as Potential Antiviral Agents
Ömer Taşpınar (Gebundene Ausgabe, Englisch)
★★★★★
☆☆☆☆☆ Keine Bewertungen vorhanden
Optischer Zustand
Beschreibung
Eurysterol A, a cytotoxic and antifungal marine steroidal sulfate with a unique C8–C19 oxy-bridged cholestane skeleton, was isolated in 2007 from a sponge of the genus Euryspongia collected in Palau. The compound was found to display cytotoxicity against HCT‐116 human carcinoma cells as well as antifungal properties against amphotericin B‐resistant strains of Candida albicans. Structurally, the… eurysterols are characterized by an unusual 8,19-epoxy cholestane skeleton with a sodium sulfate group at C3 and a 5α,6β-diol moiety. This work describes the first chemical synthesis of eurysterol A. As a key step, an intramolecular oxa-Michael addition was exploited to close the oxy-bridge (8β,19-epoxy unit). Along the optimized (scalable) synthetic sequence, the target natural product was obtained in only 11 steps in 5% overall yield. Furthermore, a first synthetic entry towards the monanchosterols, a new class of natural products possessing a steroid-analogue structure with a characteristic bicyclo[4.3.1]decane A/B ring system was developed, via intramolecular aldol reaction of a 5,6-secosterol. The elaborated access to the core structure of monanchosterols with a Δ24-saturated cholesterol side chain represents the basis for future studies towards synthesis of the natural monanchosterols and the evaluation of their biological potential. The second part of this thesis describes the synthesis of analogs of the antiviral natural houttuynoid B with different sugar moieties and side chains. Previously, it was found that a synthetic derivative of houttuynoid B (TK1023), which differs only by acetylated glycoside moiety, prevents cell entry of Zika virus. The synthesized analogs, which are currently under biological investigation, will contribute to the understanding of structure-activity relationships (SAR) of this promising class of antiviral flavonoid glycosides. Dieses Produkt haben wir gerade leider nicht auf Lager.
Handgeprüfte Gebrauchtware
Bis zu 50 % günstiger als neu
Der Umwelt zuliebe
Technische Daten
Erscheinungsdatum
22.02.2021
Sprache
Englisch
EAN
9783843946988
Herausgeber
Dr. Hut
Serien- oder Bandtitel
Organische Chemie
Sonderedition
Nein
Autor
Ömer Taşpınar
Seitenanzahl
268
Einbandart
Gebundene Ausgabe
Schlagwörter
Naturstoffsynthese, Marine Steroide, Antivirale Flavonoid-Glycoside
Thema-Inhalt
PNN - Organische Chemie
Höhe
210 mm
Breite
14.8 cm
-.-
★★★★★
☆☆☆☆☆ Leider noch keine Bewertungen
Leider noch keine Bewertungen
Sicher bei rebuy kaufen
Schreib die erste Bewertung für dieses Produkt!
Wenn du eine Bewertung für dieses Produkt schreibst, hilfst du allen Kund:innen, die noch überlegen, ob sie das Produkt kaufen wollen. Vielen Dank, dass du mitmachst!
Sicher bei rebuy kaufen