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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Biochemie & Biophysik Regulation of Membrane Na+-K+ ATPase
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Regulation of Membrane Na+-K+ ATPase
(Gebundene Ausgabe, Englisch)
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Beschreibung
Na + -K + ATPase or Na-pump ATPase, a member of “P”-type ATPase superfamily, is characterized by association of multiple isoforms mainly of it’s α- and β- subunits. At present four different α- (α-1,α-2,α-3 and α-4) and three β- (β-1, β-2, and β-3) isoforms have been identified in mammalian cells and their differential expressions are tissue specific. Regulation of Na + -K + ATPase activity is an… important but a complex process, which involves short-term and long-term mechanisms. Short-term regulation of Na + -K + ATPase is either mediated by changes in intracellular Na + concentrations that directly affect the Na + -pump activity or by phosphorylation/dephosphorylation-mediated by some stimulants leading to changes in its expression and transport properties. On the other hand, long-term regulation of Na + -K + ATPase is mediated by hormones, such as mineralocorticoids and thyroid hormones, which cause changes in the transcription of genes of α- and β- subunits leading to an increased expression in the level of Na + -pump. Several studies have revealed a relatively new type of regulation that involves the association of small, single span membrane proteins with this enzyme. These proteins belong to the FXYD family, the members of which share a common signature sequence encompassing the transmembra ne domain adjacent to the isoform(s) of α-β subunits of Na + -K + ATPase. Considering the extraordinary importance of Na + -K + ATPase in cellular function, several internationally established investigators have contributed their articles in the monograph entitled “Regulation of Membrane Na + -K + ATPase” for inspiring young scientists and graduate students to enrich their knowledge on the enzyme, and we are sure that this book will soon be considered as a comprehensive scientific literature in the area of Na + -K + ATPase regulation in health and disease. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
22.12.2015
Sprache
Englisch
EAN
9783319247489
Herausgeber
Springer International Publishing
Serien- oder Bandtitel
Advances in Biochemistry in Health and Disease
Sonderedition
Nein
Seitenanzahl
436
Einbandart
Gebundene Ausgabe
Schlagwörter
Membrane Na+-K+ ATPase, Cardiac Na+-K+ ATPase, Na+/K+-ATPase inhibitors, Na+-coupled cotransport, Na+-K+ pump, Protein Structure
Thema-Inhalt
PSB - Biochemie
PSF - Zellbiologie (Zytologie)
PHN - Kernphysik
MBGR - Medizinische Forschung
Höhe
235 mm
Breite
15.5 cm
Transparenz & Sicherheit
Hersteller: Springer Nature Customer Service Center GmbH, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com
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