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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Medizin Pharmazie The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems
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The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems
(Broschiert, Englisch)
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Beschreibung
This, the 148th volume of the Handbook of Experimental Pharmacology series, focuses on the very core of pharmacology, namely receptor theory. It is fitting that the originator of receptor pharmacology, A. J. CLARK, authored the fourth volume of this series 63 years ago. In that volume CLARK further developed his version of receptor theory first described four years earlier in his classic book The… Mode of Action of Drugs. An examination of the topics covered in volume 4 reveals a striking similarity to the topics covered in this present volume; pharmacologists today are still as interested in unlocking the secrets of dose-response relationships to reveal the biological and che mical basis of drug action as they were over half a century ago. Sections in that 1937 volume such as "Curves relating exposure to drugs with biological effects" and "Implications of monomolecular theory" show Clark's keen insight into the essential questions that required answers to move pharma cology forward. With the advent of molecular biological cloning of human receptors has come a transformation of receptor pharmacology. Thus the expression of human receptors into surrogate host cells helped unlock secrets of receptor mechanisms and stimulus-transduction pathways. To a large extent, this elim inates the leap of faith required to apply receptor activity of drugs tested on animal receptor systems to the human therapeutic arena. However, a new leap of faith concerning the veracity of the effects found in recombinant systems with respect to natural ones is now required. 90,94 €
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Technische Daten
Erscheinungsdatum
24.10.2012
Sprache
Englisch
EAN
9783642630286
Herausgeber
Springer Berlin
Serien- oder Bandtitel
Handbook of Experimental Pharmacology
Sonderedition
Nein
Seitenanzahl
448
Auflage
1
Einbandart
Broschiert
Bandzählung
148
Schlagwörter
Pharmakologie, Rezeptor, cardiovascular pharmacology, in vitro pharmacology, physiology, receptor theory, recombinant receptor systems, tissue
Thema-Inhalt
MKG - Pharmakologie
MFG - Physiologie
PSB - Biochemie
MBGR - Medizinische Forschung
Höhe
235 mm
Breite
15.5 cm
Transparenz & Sicherheit
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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