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Bücher Wissen & Bildung Englische Bücher Naturwissenschaft, Medizin, Informatik, Technik Biologie Biochemie & Biophysik Red Cell Membrane Transport in Health and Disease
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Red Cell Membrane Transport in Health and Disease
(Broschiert, Englisch)
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Beschreibung
The red cell has been a focus for scientific and medical investigation since the ear liest times. A higher erythrocyte sedimentation rate was associated with diseases (usually pyrexias) before the thermometer was invented. Furthermore, ever since the early observers Swammerdam and Leeuvenhoek saw discrete corpuscles in samples of blood using the first microscopes, there has been a significant… scientific interest in the structure and function of red blood cells. The later discovery that red cells were not spherical, but biconcave discs introduced a scientific puzzle which is still not completely resolved today, and identified the need for a detailed knowledge of the plasma membrane composition and structure, and its interaction with the cytoskeleton. Important concepts like the lipid bilayer, together with its more recent refinement as asymmetric in phospholipid composition led to the identification of translocases involved in actively maintaining its composition. Understanding the mechanics of red cell deformation as these biconcave discs traverse capillaries was advanced by the pioneering work of Rand and Burton in the Sixties, and progressed by Evans, Skalak and others. Based on the bilayer couple hypothesis, the shape changes that are possible for a human red cell from echinocyte to stomatocyte were described by Sheetz and Singer in the Seventies in terms of alterations in the individual halves of the bilayer. Certain clinical condi tions are associated with obvious changes in red cell morphology. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
19.12.2010
Sprache
Englisch
EAN
9783642079207
Herausgeber
Springer Berlin
Sonderedition
Nein
Seitenanzahl
748
Einbandart
Broschiert
Schlagwörter
Transporter, biomechanics, biophysics, blood, blood cell, cell, cell membrane, cells, dynamics, erythrocyte, mechanics, membrane, pathophysiology, physiology, water
Thema-Inhalt
PHVN - Biophysik
PSA - Biowissenschaften, allgemein
MBGR - Medizinische Forschung
MJF - Hämatologie
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer Spektrum, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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