Heparanase

10.04.2021

Englisch

9783030345235

Springer International Publishing

Advances in Experimental Medicine and Biology

Nein

885

Broschiert

From Basic Research to Clinical Applications

Israel Vlodavsky is a Professor of Cancer and Vascular Biology at Technion- Israel Institute of Technology’s Rappaport Faculty of Medicine and Technion Integrated Cancer Center (TICC). Vlodavsky’s discovery of the extracellular matrix as a reservoir for bioactive molecules provided the basis for the current appreciation of the tumor microenvironment and its significance in cancer progression and treatment. A pioneering achievement of Vlodavsky is the cloning and characterization of heparanase, the predominant enzyme that degrades heparan sulfate and fulfills important roles in tissue remodeling, cancer metastasis, angiogenesis, inflammation, diabetes, and kidney dysfunction. Through the combination of basic and translational research, Vlodavsky is the leading scientist in this area of research, offering basic insights and new treatment strategies for various cancers and other diseases. He earned his bachelor’s and Master’s degrees from The Hebrew University of Jerusalem,and Ph.D. from the Weizmann Institute, Rehovot, Israel. Ralph Sanderson is the UAB Endowed Professor of Cancer Pathobiology and Director, Division of Molecular and Cellular Pathology, Department of Pathology, UAB O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham. Sanderson earned a B.S. from the University of Alabama, and a Ph.D. at the University of Alabama at Birmingham. His research focuses on determining how tumor-host cell interactions mediated by heparan sulfate and the enzyme heparanase regulate the tumor microenvironment and promote tumor progression, and to use that knowledge to design new cancer therapies.

heparanase, carcinoma, sarcoma, cell microenvironment, metastasis, angiogenesis, hematological malignancies, heparin sulfate

MJCL - Onkologie MBGR - Medizinische Forschung

235 mm

15.5 cm