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Bücher Wissen & Bildung Englische Bücher Naturwissenschaft, Medizin, Informatik, Technik Chemie Organische Chemie The Chemistry of β-Lactams
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Beschreibung
It is over sixty years since Alexander Fleming observed antibiosis between a Penicillium mould and bacterial cultures and gave the name penicillin to the active principle. Although it was proposed in 1943 that penicillin (1) contained a tJ-Iactam ring, this was not generally accepted until an X-ray crystallographic determination of the structure had been completed. RCONH )=r)< o '" (I) 'C0 H 2… Penicillin was the first naturally occurring antibiotic to be characterised and used in clinical medicine. It is now seen as the progenitor of the tJ-Iactam family of antibiotics, which are characterised by the possession of the four membered tJ-Iactam ring. Chapters in this book will describe how current research has demonstrated that other lactam structures may also show antibacterial activity. Penicillins and cephalosporins (2), the second member of the tJ-Iactam antibiotic family, were both originally discovered in fungi but later detected in streptomycetes. Until 1970 penicillins and cephalosporins were the only examples of naturally occurring tJ-Iactam antibiotics. The discovery of 7-a-methoxy cephalosporins (3) from Streptomyces in 1971 stimulated the search for novel tJ-Iactam antibiotics from microbes, both by using sensitive new screening procedures, and by laboratory synthesis. 53,49 €
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Technische Daten
Erscheinungsdatum
29.10.2012
Sprache
Englisch
EAN
9789401053006
Herausgeber
Springer Netherland
Sonderedition
Nein
Seitenanzahl
351
Einbandart
Broschiert
Schlagwörter
Peptid, chemistry, enzyme, enzymes, protein, proteins, synthesis
Thema-Inhalt
PNN - Organische Chemie
PSB - Biochemie
Höhe
235 mm
Breite
15.5 cm
Transparenz & Sicherheit
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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