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Dual frequency Magnetic Particle Imaging Scanner - Hardware for mobilityMPI

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Dual frequency Magnetic Particle Imaging Scanner - Hardware for mobilityMPI

Christian Kuhlmann (Unbekannter Einband, Englisch)

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Magnetic Particle Imaging (MPI), being a new tomographic imaging modality based on magnetic nanoparticle tracers, offers potential applications in medicine and medical research that may complement or even replace current radiological methods such as single-photon emission computed tomography (SPECT) and positron emission tomographie (PET). Offering similar spatial resolution in the millimeter range and high temporal resolution with several images per second, it is well suited to be useful for many applications that require high contrast with no interfering anatomical background signal. Since MPI doesn’t rely on ionizing radiation, substitution of radiological methods benefits the safety of patients and medical staff. One of the challenges, besides delivering high sensitivity that can compete with these existing methods, is to provide capabilities that surpass what is currently possible with tracer based imaging systems. A possible advantage of the MPI method is the presence of nanoparticle tracers that can be modified to interact in well defined ways with their environment through surface functionalization. By exploiting particle dynamics, these interactions can be measured magnetically using MPI and can provide a spatially resolved map of particles states, enabling functional imaging on a quantitative basis. Several points need to be addressed in order to enable functional imaging with MPI: Suitable biocompatible tracers need to be developed that possess the desired surface functionalization and are suitable for MPI, particle dynamics of these tracers need to be well understood and modeling techniques should be available to predict particle behavior accurately enough to derive useful information from the particle signal, and MPI scanners suitable for the task of detecting particle mobility need to be constructed. This work describes the development and application of a MPI scanner that is designed specifically to demonstrate and further research the functional imaging capability ofMPI through the measurement of particle mobility information. This concept, called moblity MPI (mMPI), can be realized through several techniques, all of which are based on the Brownian relaxation mechanism. One of these techniques involves the use of multiple excitation frequencies, that can be used to separate information on the spatial distribution from particle dynamics. Since the particle relaxation is inherently dependent on the excitation frequency and since for many particle tracers an additional contribution from theNéel relaxation exits, acquiring the same image at several drive frequencies can provide the additional data required for functional and spatially resolved MPI. Since all current MPI scanners rely on transmit and receive chains that are tuned to the excitation frequency, the scanner hardware needs to be adapted for this multi-frequency approach. Starting from the design of a multi-frequency magnetic particle spectrometer (MPS) that was later used to carry out pre-experiments on suitable tracer systems, this thesis describes in detail the design and construction of a mMPI system and its components. Several useful design techniques, such as a method for the accurate prediction of excitation coil parasitics, have been developed for this task. Other noteworthy aspects are the design of transmit and receive filters that offer high stop band attenuation and good linearity as required for MPI. The development of a fully differential receive coil completes the effort to provide a system suitable for the demonstration of mMPI. All system components have been thoroughly characterized to validate that the requirements have been met. After acquiring conventional one- and two-dimensional MPI images, the new scanner was used to investigate the capability of MPI to provide spatially resolved information on particle mobility. Samples with different viscosities have been used to that end to simulate the effect of different binding states on the particles. Weniger zeigen

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Produktinformationen

Technische Daten

Erscheinungsdatum

20.11.2018

Sprache

Englisch

EAN

9783863879372

Herausgeber

Mensch & Buch

Serien- oder Bandtitel

Elektrische Messtechnik und Grundlagen der Elektrotechnik

Sonderedition

Nein

Autor

Christian Kuhlmann

Seitenanzahl

238

Auflage

Einbandart

Unbekannter Einband

Warnhinweise und Sicherheitsinformationen

Informationen nach EU Data Act

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