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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Medizin Nichtklinische Fächer Obesity and Breast Cancer
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Obesity and Breast Cancer
Kristy A. Brown, Evan R. Simpson (Broschiert, Englisch)
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Beschreibung
Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are… negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters. Targeting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer. Aromatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast. This SpringerBrief will explore all of these issues in depth and the authors are in a unique position to write about this topic, having extensive experience in the field of aromatase research. 53,49 €
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Technische Daten
Erscheinungsdatum
21.11.2013
Sprache
Englisch
EAN
9781489980014
Herausgeber
Springer US
Serien- oder Bandtitel
SpringerBriefs in Cancer Research
Sonderedition
Nein
Autor
Kristy A. Brown, Evan R. Simpson
Seitenanzahl
56
Einbandart
Broschiert
Buch Untertitel
The Role of Dysregulated Estrogen Metabolism
Schlagwörter
breast cancer, menopause, metabolism, obesity, oestrogen, metabolic disease
Thema-Inhalt
MJCL - Onkologie
MJC - Krankheiten und Störungen
PSE - Chemische Biologie
Höhe
235 mm
Breite
15.5 cm
Transparenz & Sicherheit
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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