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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Zoologie Integration of Pharmaceutical Discovery and Development
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Integration of Pharmaceutical Discovery and Development
(Broschiert, Englisch)
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Beschreibung
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str-… egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred. 213,99 €
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Technische Daten
Erscheinungsdatum
07.12.2010
Sprache
Englisch
EAN
9781441932884
Herausgeber
Springer US
Serien- oder Bandtitel
Pharmaceutical Biotechnology
Sonderedition
Nein
Seitenanzahl
610
Einbandart
Broschiert
Buch Untertitel
Case Histories
Schlagwörter
Nucleoside, chemistry, development, metabolism, pharmaceutical, receptor
Thema-Inhalt
PSV - Zoologie und Tierwissenschaften
PSB - Biochemie
Höhe
229 mm
Breite
15.2 cm
Transparenz & Sicherheit
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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