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Beschreibung
Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed… light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events. 192,59 €
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Technische Daten
Erscheinungsdatum
29.09.2022
Sprache
Englisch
EAN
9783030784386
Herausgeber
Springer International Publishing
Sonderedition
Nein
Seitenanzahl
679
Auflage
1
Einbandart
Broschiert
Buch Untertitel
The Art and Science of Modulator Design and Discovery
Schlagwörter
molecular pharmacology, drug design, PPAR, PXR, metabolic diseases, vitamin d receptor, ligand, target transcription, RXR Phosphorylation, RXRalpha, neuropathy, therapeutic strategies, phytochemicals, androgen receptors, inflammatory disease, infectious diseases, ROR inverse agonists
Thema-Inhalt
MBGR - Medizinische Forschung
PNB - Medizinische Chemie, Pharmazeutische Chemie
Höhe
235 mm
Breite
15.5 cm
Transparenz & Sicherheit
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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