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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Medizin Nichtklinische Fächer Histone Mutations and Cancer
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Beschreibung
This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant… cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
07.11.2020
Sprache
Englisch
EAN
9789811581038
Herausgeber
Springer Singapore
Serien- oder Bandtitel
Advances in Experimental Medicine and Biology
Sonderedition
Nein
Seitenanzahl
96
Auflage
1
Einbandart
Gebundene Ausgabe
Autorenporträt
Dr. Dong Fang received his Ph.D. from Tsinghua University, China in 2012. After that, he worked for four years at the Mayo Clinic, USA, where he focused on understanding the role of epigenetic regulation of gene expression and on how oncohistones reprogram the epigenetic landscape and gene expression to drive tumorigenesis. In 2016, he joined the Institute for Cancer Genetics, Columbia University Medical Center, New York, USA as an Associate Research Scientist, and continued his research on oncohistones. He joined Zhejiang University in 2018, and has since established his own laboratory at its Life Sciences Institute, focusing on histone mutations and epigenetic inheritance.
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Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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