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Bücher Wissen & Bildung Englische Bücher Naturwissenschaft, Medizin, Informatik, Technik Technik Chemische Technik Spectroscopic and Mechanistic Studies of Dinuclear Metallohydrolases and Their Biomimetic Complexes
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Spectroscopic and Mechanistic Studies of Dinuclear Metallohydrolases and Their Biomimetic Complexes
Lena Josefine Daumann (Broschiert, Englisch)
Optischer Zustand
Beschreibung
Lena Daumanns's thesis describes structural and functional studies of the enzyme Glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes. It also examines the properties of small mimics of this enzyme and related binuclear metallohydrolases such as the metallo-ß-lactamases to enhance our understanding of hydrolytic cleavage of important substrates like phosphoesters and β-lactams. Overall,… this project has led to a better understanding of the metal ion binding and active site structural features of the enzyme GpdQ. Daumann describes how she successfully immobilized phosphoesterase and related biomimetics on solid supports for potential applications in the area of bioremediation of organophosphate pesticides. Analysis shows that both the enzyme and biomimetics can be stored on the solid support without loss of activity. Furthermore, the author specroscopically and mechanistically characterized a number of Zn(II), Cd(II) and Co(II) complexes, some of which are among the most active biomimetics towards organophosphates reported to date. This thesis makes excellent reading for non-specialists because each chapter includes a short introduction section. 106,99 €
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Technische Daten
Erscheinungsdatum
10.09.2016
Sprache
Englisch
EAN
9783319360980
Herausgeber
Springer International Publishing
Serien- oder Bandtitel
Springer Theses
Sonderedition
Nein
Autor
Lena Josefine Daumann
Seitenanzahl
239
Einbandart
Broschiert
Autorenporträt
Lena Daumann holds a Diploma in Chemistry from the University of Heidelberg, Germany, where she worked with Professor Peter Comba. After gathering six months industrial experience at the BASF chemical company, she commenced her PhD in 2010 at the University of Queensland, Australia, under the supervision of Professor Lawrence Gahan. She received her doctoral degree in 2013 in the field of Bioinorganic Chemistry and currently holds a position as a postdoctoral researcher at the University of California, Berkeley, in the group of Professor Kenneth Raymond, funded by a fellowship of the Humboldt Foundation.
Schlagwörter
Antibiotic Resistance, Bioinspired Hydrolysis, Biomimetic Complex, Dinuclear Cobalt Complexes Magnetism, Magnetic Circular Dichrosim, Metallo-beta-lactamase, Organophosphate Pesticide Bioremediation, Phosphoesterase Enzymes, biochemical engineering
Thema-Inhalt
TCB - Biotechnologie
PSE - Chemische Biologie
PNFS - Spektroskopie, Spektrochemie, Massenspektrometrie
Höhe
235 mm
Breite
15.5 cm
Transparenz & Sicherheit
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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