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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Medizin Nichtklinische Fächer The Blood-Brain Barrier, Amino Acids and Peptides
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The Blood-Brain Barrier, Amino Acids and Peptides
M. Segal, Berislav V. Zlokovic (Broschiert, Englisch)
Optischer Zustand
Beschreibung
Definition of the barrier The interstitial fluid (rSF) of the brain is separated from the blood by the blood-brain barrier (BBB). This barrier must not be thought of as a single entity or as an absolute restriction to all molecules, but as a multiple structure located at several sites within the brain. The first of these interfaces is located at the endothelium of the brain capillaries. Secondly… there is a potential site for interchange on the outer linings of the brain between the dura and the arachnoid membranes. Thirdly, there are the choroid plexuses and the cerebrospinal fluid (CSF) which is in contact with the very permeable internal ependymal lining of the brain (Figure 1. 1). Finally there are areas of the brain which lack a blood-brain barrier. These areas constitute the circumventricu lar organs and have leaky capillaries with a barrier at the ependyma which limits the spread of molecules from those regions (Figure 1. 2). Each of these BBB sites has its own characteristic permeability and transport functions. We will now consider the properties of each of these barrier sites between the blood and the brain. THE CEREBRAL CAPILLARY ENDOTHELIUM Morphology This interface has both the largest surface area and the shortest path length between the blood and the brain rSF. The cerebral capillaries, which at first sight seem little different from the rest of the systemic circulation, are in fact unique to the brain. 160,49 €
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Technische Daten
Erscheinungsdatum
01.10.2011
Sprache
Englisch
EAN
9789401075008
Herausgeber
Springer Netherland
Sonderedition
Nein
Autor
M. Segal, Berislav V. Zlokovic
Seitenanzahl
202
Einbandart
Broschiert
Schlagwörter
blood, brain, interaction, proteins
Thema-Inhalt
PSAN - Neurowissenschaften
MJCM - Immunologie
MKF - Pathologie
Höhe
235 mm
Breite
15.5 cm
Transparenz & Sicherheit
Hersteller: Springer Nature Customer Service Center GmbH, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com
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