iPhoneAlle anzeigen
iPhone 11iPhone 11 ProiPhone 11 Pro MaxiPhone 12iPhone 12 ProiPhone 12 Pro MaxiPhone 12 miniiPhone 13iPhone 13 ProiPhone 13 Pro MaxiPhone 13 miniiPhone 14iPhone 14 PlusiPhone 14 ProiPhone 14 Pro MaxiPhone 15iPhone 15 PlusiPhone 15 ProiPhone 15 Pro MaxiPhone 16iPhone 16 PlusiPhone 16 ProiPhone 16 Pro MaxiPhone 16eiPhone 8iPhone 8 PlusiPhone SE 2020iPhone SE 2022iPhone XiPhone XRiPhone XSiPhone XS Max
Galaxy A-SerieAlle anzeigen
Galaxy A12Galaxy A13Galaxy A13 5GGalaxy A14Galaxy A15Galaxy A16Galaxy A17 5GGalaxy A20eGalaxy A21Galaxy A22Galaxy A23Galaxy A24Galaxy A25Galaxy A26 5GGalaxy A32Galaxy A33Galaxy A34Galaxy A35Galaxy A36 5GGalaxy A40Galaxy A41Galaxy A42Galaxy A50Galaxy A51Galaxy A52Galaxy A53Galaxy A54Galaxy A55Galaxy A56 5GGalaxy A70Galaxy A71Galaxy A72
Redmi SeriesAlle anzeigen
Redmi 10Redmi 13CRedmi 15 5GRedmi Note 10Redmi Note 10 ProRedmi Note 11Redmi Note 11 ProRedmi Note 11 Pro Plus 5GRedmi Note 11sRedmi Note 12Redmi Note 12 5GRedmi Note 12 ProRedmi Note 12 Pro 5GRedmi Note 12 Pro PlusRedmi Note 13Redmi Note 13 5GRedmi Note 13 ProRedmi Note 13 Pro PlusRedmi Note 14Redmi Note 14 Pro PlusRedmi Note 8Redmi Note 8 ProRedmi Note 9Redmi Note 9 Pro
- Startseite
Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Mikrobiologie Micro- and Macroparticle enhanced cultivation of filamentous Lentzea aerocolonigenes for increased rebeccamycin production
Derzeit nicht verfügbar
Handgeprüfte Gebrauchtware
Bis zu 50 % günstiger als neu
Der Umwelt zuliebe
Micro- and Macroparticle enhanced cultivation of filamentous Lentzea aerocolonigenes for increased rebeccamycin production
Kathrin Schrinner (Unbekannter Einband, Englisch)
★★★★★
☆☆☆☆☆ Keine Bewertungen vorhanden
Optischer Zustand
Beschreibung
The filamentous actinomycete Lentzea aerocolonigenes produces the antitumor antibiotic rebeccamycin. However, the complex morphology of actinomycetes leads to challenges during the cultivation often accompanied by low product titers. In the recent past, the to date low rebeccamycin titers were increased by particle addition to cultivations of L. aerocolonigenes. In this thesis the addition of… micro-, macro- and adsorbent particles to cultivations of L. aerocolonigenes were investigated in more detail. Furthermore, the scale-up to a bubble-free bioreactor was conducted.
The addition of glass microparticles (x50 = 7.9 μm, 10 g L-1) to shake flask cultivations increased the rebeccamycin titer up to 3.6-fold compared to an unsupplemented approach. Pellet slices showed the incorporation of microparticles. With different surface modifications of the microparticles, specific incorporation patterns of the microparticles appeared. The incorporation of microparticles causes looser and smaller pellets allowing an increased nutrient and oxygen supply in the pellet core. With addition of larger (glass) macroparticles (ø = 0.2 – 2.1 mm, 100 g L-1) mechanical stress was induced on the biopellets. The additional supplementation of 5 g L-1 soy lecithin and glass beads (ø = 969 μm, 100 g L-1) resulted in a rebeccamycin titer of 388 mg L-1, one of the highest rebeccamycin titers ever achieved. For the scale-up of L. aerocolonigenes cultivations a bubble-free membrane aeration system was developed. The tubular membrane aeration system can additionally be pressurized to increase the oxygen transfer. First cultivations of L. aerocolonigenes successfully provided 18 mg L-1 rebeccamycin, a concentration similar to that of unsupplemented shake flask cultivations. XAD adsorbent particles were added to cultivations to facilitate rebeccamycin recovery. However, the XAD particles additionally increased the rebeccamycin titer which was likely to be caused by the adsorption of the rebeccamycin precursor tryptophan to the resins which in turn directly transferred the tryptophan to the microorganism Dieses Produkt haben wir gerade leider nicht auf Lager.
Handgeprüfte Gebrauchtware
Bis zu 50 % günstiger als neu
Der Umwelt zuliebe
Technische Daten
Erscheinungsdatum
05.01.2021
Sprache
Englisch
EAN
9783736973503
Herausgeber
Cuvillier Verlag
Serien- oder Bandtitel
Schriftenreihe des Institutes für Bioverfahrenstechnik der Technischen Universität Braunschweig
Sonderedition
Nein
Autor
Kathrin Schrinner
Seitenanzahl
142
Auflage
1
Einbandart
Unbekannter Einband
-.-
★★★★★
☆☆☆☆☆ Leider noch keine Bewertungen
Leider noch keine Bewertungen
Sicher bei rebuy kaufen
Schreib die erste Bewertung für dieses Produkt!
Wenn du eine Bewertung für dieses Produkt schreibst, hilfst du allen Kund:innen, die noch überlegen, ob sie das Produkt kaufen wollen. Vielen Dank, dass du mitmachst!
Sicher bei rebuy kaufen