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Bücher Wissen & Bildung Englische Bücher Naturwissenschaft, Medizin, Informatik, Technik Biologie Biochemie & Biophysik Cellular Signaling in Health and Disease
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Cellular Signaling in Health and Disease
Martin Beckerman (Broschiert, Englisch)
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Beschreibung
In today’s world, three great classes of non-infectious diseases – the metabolic syndromes (such as type 2 diabetes and atherosclerosis), the cancers, and the neurodegenerative disorders – have risen to the fore. These diseases, all associated with increasing age of an individual, have proven to be remarkably complex and difficult to treat. This is because, in large measure, when the cellular… signaling pathways responsible for maintaining homeostasis and health of the body become dysregulated, they generate equally stable disease states. As a result the body may respond positively to a drug, but only for a while and then revert back to the disease state. Cellular Signaling in Health and Disease summarizes our current understanding of these regulatory networks in the healthy and diseased states, showing which molecular components might be prime targets for drug interventions. This is accomplished by presenting models that explain in mechanistic, molecular detail how a particular part of the cellular signaling web operates properly in health and improperly in disease. The stability of the health- and disease-associated states is dynamic and supported by multiple feedback loops acting positively and negatively along with linkages between pathways. During the past few years an ongoing series of important discoveries have been made that advance our understanding of how the body works and may guide us on how to better deal with these diseases. These include the discovery of chronic inflammation as a causal factor in all of these disease classes, the appearance of reactive oxygen species as a messenger molecule that can act both positively and negatively, the propensity of proteins to misfold into aggregation- and disease-prone forms, and the rise of epigenetics including the emergence of small non-coding RNA with important regulatory functions out of the so-called junk RNA. Chapters are devoted to each of these classes of findings with additional detailsintegrated into the chapters dealing directly with the diseases. The connections responsible for maintaining stability are explored in depth. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
06.12.2010
Sprache
Englisch
EAN
9781441931092
Herausgeber
Springer US
Serien- oder Bandtitel
Biological and Medical Physics, Biomedical Engineering
Sonderedition
Nein
Autor
Martin Beckerman
Seitenanzahl
470
Auflage
1
Einbandart
Broschiert
Schlagwörter
Tissue Engineering, disease cell signaling, homeostasis book, proteins, regulatory networks book, signaling pathways book, tissue
Thema-Inhalt
PHVN - Biophysik
MFG - Physiologie
PSF - Zellbiologie (Zytologie)
MBGR - Medizinische Forschung
MQW - Biomedizinische Technik
PSB - Biochemie
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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