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Formulating Poorly Water Soluble Drugs

(Gebundene Ausgabe, Englisch)

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Beschreibung
The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facetsand detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.
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Technische Daten


Erscheinungsdatum
20.05.2022
Sprache
Englisch
EAN
9783030887186
Herausgeber
Springer International Publishing
Serien- oder Bandtitel
AAPS Advances in the Pharmaceutical Sciences Series
Sonderedition
Nein
Seitenanzahl
693
Auflage
3
Einbandart
Gebundene Ausgabe
Autorenporträt
Robert O. (Bill) Williams is the Johnson & Johnson Centennial Chair and Professor of Pharmaceutics and the Division Head of Molecular Pharmaceutics and Drug Delivery at the College of Pharmacy, University of Texas at Austin. He earned a B.S. in Biology from Texas A&M University, a B.S. in Pharmacy from the University of Texas at Austin and Doctor of Philosophy in Pharmaceutics in 1986 from the University of Texas at Austin. Dr. Williams worked 9 years in the pharmaceutical industry in the United States and France before returning to the University of Texas at Austin in 1995. Dr Williams was elected Fellow of the American Association of Pharmaceutical Scientists in 2006, Fellow of the American Institute of Medical and Biological Engineering in 2008 and Fellow of the National Academy of Inventors in 2019. He was named the Inventor of the Year by the University of Texas at Austin in 2017. Dr. Williams is a member of the American Association of Pharmaceutical Scientists (AAPS), as well as other professional societies including the American Association of Colleges of Pharmacy. He is the co-founder of several pharmaceutical companies. Dr. Williams’ research interests include development of novel drug delivery systems for oral, pulmonary, nasal, injectable, buccal and topical applications, development of novel particle engineering technologies for low molecular weight drugs, peptides and proteins, and analytical technologies to characterize actives, excipients and polymers. He has published over 500 peer-reviewed research articles, reviews, abstracts and book chapters, and co-edited two books in the fields of pharmaceutical technology and drug delivery, including Formulating Poorly Water Soluble Drugs, Second Edition (aapspress and Springer). He is an inventor on over 45 patents and patent applications. Dr. Williams served as Editor-in-Chief of the research journal Drug Development and Industrial Pharmacy from 2000 to 2014 and is the Editor-in-Chief of AAPS PharmSciTech since 2014. He is on the Editorial Advisory Board of Journal of Drug Delivery Science and Technology and International Journal of Pharmaceutics and he serves as a reviewer for numerous other journals.
Schlagwörter
bioavailability, lipophilic, solubility, dissolution, formulation development, nanoparticle processes, amorphous systems, drug delivery, route-specific challenges, drug dosage design
Thema-Inhalt
PNB - Medizinische Chemie, Pharmazeutische Chemie MKG - Pharmakologie
Höhe
254 mm
Breite
17.8 cm

Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH

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