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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Genetik & Gentechnik Drug Delivery to the Brain
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Beschreibung
The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood–brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to… name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with anemphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
25.05.2022
Sprache
Englisch
EAN
9783030887728
Herausgeber
Springer International Publishing
Serien- oder Bandtitel
AAPS Advances in the Pharmaceutical Sciences Series
Sonderedition
Nein
Seitenanzahl
806
Auflage
2
Einbandart
Gebundene Ausgabe
Buch Untertitel
Physiological Concepts, Methodologies and Approaches
Schlagwörter
blood-brain barrier, drug delivery blood-brain barrier, transporters, CNS drug delivery, CNS PK and PD, BBB
Thema-Inhalt
TCB - Biotechnologie
PSAN - Neurowissenschaften
MBGR - Medizinische Forschung
PNB - Medizinische Chemie, Pharmazeutische Chemie
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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