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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Mathematik Wahrscheinlichkeitstheorie & Statistik Statistical Design and Analysis of Biological Experiments
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Statistical Design and Analysis of Biological Experiments
Hans-Michael Kaltenbach (Broschiert, Englisch)
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Beschreibung
This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response… surface methods for optimizing experimental conditions or biotechnological yields. The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including ‘portable power’ formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice. Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software. Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
17.04.2022
Sprache
Englisch
EAN
9783030696436
Herausgeber
Springer International Publishing
Serien- oder Bandtitel
Statistics for Biology and Health
Sonderedition
Nein
Autor
Hans-Michael Kaltenbach
Seitenanzahl
269
Einbandart
Broschiert
Autorenporträt
Dr. Kaltenbach is a Senior Scientist at the ETH Zurich, Switzerland. He holds a diploma in mathematics and a PhD in bioinformatics, and previously worked in industry as a statistical consultant. His research combines statistics and applied mathematics in the context of biology and medicine. He is the author of
Schlagwörter
Experimental design, ANOVA, linear mixed model, completely randomized design, sample size, design for improving precision, blocked designs, assay qualification, Hasse diagram, optimizing experimental conditions, Response surface methods, Factorial design
Thema-Inhalt
PBT - Wahrscheinlichkeitsrechnung und Statistik
PSAX - DV-gestützte Biologie/Bioinformatik
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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