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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Chemie Organische Chemie Shining bright: Fluorescent tools for drug discovery, development and delivery
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Shining bright: Fluorescent tools for drug discovery, development and delivery
Bettina Olshausen (Unbekannter Einband, Englisch)
★★★★★
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Beschreibung
In chemical biology, the fluorescent labeling of molecules and usage of fluorescence-based imaging techniques for visualizing molecular interactions at a subcellular level is a key feature and contributes significantly to the elucidation of disease mechanisms. Furthermore, potential drug target sites can be identified, drugs acting on such sites can be developed, and by their labeling, the… interactions of drugs and targets can be uncovered. In this work, innovative approaches for the fluorescent labeling of proteins, nucleic acids, and drugs are presented. A novel methodology for the facile synthesis of a versatile, functionalized, water-soluble, and tunable fluorescent probe has been developed. As a class of promising drug candidates, oligonucleotides were labeled in a dual-color readout DNA/RNA “Traffic Lights” concept that allows reliable tracking of cellular delivery, target binding, and structural integrity of nucleic acids. To ensure efficient early detection of diseases, a melanocyte-specific compound has been synthesized with the goal of enabling melanoma detection via non-invasive fluorescence microscopy. Once a cancerous disease with a solid tumor is detected, the efficient transport of a drug to the tumor site and local accumulation is of meaningful impact. A polymeric nanocarrier system for targeted tumor transport and triggered drug release has been developed. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
25.06.2018
Sprache
Englisch
EAN
9783736998162
Herausgeber
Cuvillier Verlag
Sonderedition
Nein
Autor
Bettina Olshausen
Seitenanzahl
216
Auflage
1
Einbandart
Unbekannter Einband
Schlagwörter
drug uptake, BODIPY, tumor targeting, fluorescence, biologically active molecules, drug target, DNA/RNA traffic lights, polymer, drug development, oligonucleotides, styryl dye, drug delivery, imaging, fluorescent dyes, synthesis, Lipinski, rule of 5, disease, fluorescence microscopy, early detection, EPF effect, siRNA, side effects, dye, fluorescein, visualization, tumor, melanoma, nanocarrier, melanoma diagnostics, cyanin dye, targeted drug delivery, drug discovery, chemical biology, specific uptake, drug efficacy
Thema-Inhalt
MBGL - Medizinische Laboruntersuchungen und -techniken
MBGR - Medizinische Forschung
Höhe
210 mm
Breite
14.8 cm
-.-
★★★★★
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