Inhalation therapy is a form of treatment for respiratory diseases. However, a major disadvantage of inhalation therapy with continuous drug delivery to the patient is the waste of drugs during exhalation. The development of a breath-triggered drug delivery system can greatly reduce this waste. Furthermore, in preterm and term neonates, this is further complicated by their challenging respiratory… Mehr zeigen parameters such as high respiratory rate, low tidal volume, and short inhalation times. Given these challenges, there is currently no technology that enables breath-triggered drug release directly at the patient interface of preterm and term neonates. To close this gap, it is not only necessary to develop devices that enable efficient drug release at high frequencies, but also test beds that can be used to determine the efficiency of drug release. Moreover, the respiratory phases must be detected to release the aerosol in synchrony with the respiration. Therefore, an overall system consisting of aerosol output determination, breath-triggered aerosol release, and breath detection published by Wiegandt et al. is presented in this thesis as follows: 1. A test bed, consisting of gravimetric and optical particle detection which allows the determination of the aerosol output in real time as well as the determination of the particles' water content. 2. A breath-triggered aerosol delivery system consisting of a novel patient interface with an integrated micronized aerosol valve which allows direct and rapid breath-triggered delivery of aerosol as a targeted bolus at different times of inhalation. 3. A respiratory detection system consisting of a time-of-flight camera for recording the abdominal movement of preterm neonates which enables the determination of respiratory parameters. Weniger zeigen

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Produktinformationen

Technische Daten

Erscheinungsdatum

30.12.2022

Sprache

Englisch

EAN

9783844088700

Herausgeber

Shaker

Serien- oder Bandtitel

Schriftenreihe Mikrotechnik

Sonderedition

Nein

Autor

Felix Carl Wiegandt

Seitenanzahl

102

Einbandart

Broschiert

Einbandart Details

Klebebindung

Schlagwörter

aerosol, time-of-flight camera, test bed, abdominal movement, breath-triggered drug release, preterm infant, optical detection, preterm neonate, real-time measurement

Thema-Inhalt

MBG - Medizinische Ausstattung und Technik TTW - Heil- und Hilfsmittel, Assistive Technologie

Höhe

210 mm

Breite

14.8 cm

Warnhinweise und Sicherheitsinformationen

Informationen nach EU Data Act

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