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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Chemie Physikalische Chemie The Medicinal Chemistry of Glucocorticoid Receptor Modulators
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The Medicinal Chemistry of Glucocorticoid Receptor Modulators
Adrian Hobson (Broschiert, Englisch)
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Beschreibung
This book covers the design and development of glucocorticoid receptor modulators (GRM) from cortisol to antibody-drug conjugate payloads over the last 70 years. The author starts with an introduction to the background of glucocorticoid receptor modulators as potential therapeutic modalities. This is followed by seven chapters in which he collates and discusses the medicinal chemistry journey of… GRMs, reviewing topics such as cortisol-based glucocorticoids, the different approaches that have been pursued to enable chronic dosing of GRM compounds by inactivation in plasma and the liver, the application of prodrugs to GRMs, selective GRMs, targeted delivery of GRMs using polymers and nanoparticles, and rational drug design approaches applied in the development of GRMs. Particular attention is given to the development of glucocorticoid receptor modulators as immunology antibody-drug conjugate payloads. In the book’s final chapter, the author critiques the medicinal chemistry progress madesince the discovery of cortisone and the promise of the latest antibody-drug conjugates that release a GRM payload. In this book, readers will also find an overview of the X-ray structures of glucocorticoid receptor antagonists and a list of all the earlier reviews that cover part of the medicinal chemistry story of GRM collated by keywords organized in a table. With several examples of crystal structures and molecular modeling, this book illustrates the huge effort by multiple companies and research groups to develop glucocorticoid receptor modulators. Professionals and scholars alike will find it a handy tool, and appreciate the latest research findings that it presents. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
12.04.2023
Sprache
Englisch
Originalsprache
Englisch
EAN
9783031287312
Herausgeber
Springer International Publishing
Serien- oder Bandtitel
SpringerBriefs in Molecular Science
Sonderedition
Nein
Autor
Adrian Hobson
Seitenanzahl
142
Einbandart
Broschiert
Schlagwörter
Antibody Drug Conjugates, Glucocorticoid Receptor Modulators (GRM), Prodrugs, Metabolic Inactivation, Targeted Therapy, QSAR and Modeling, Selective glucocorticoid receptor modulators, Steroids, Drug Development, Drug Delivery
Thema-Inhalt
PNB - Medizinische Chemie, Pharmazeutische Chemie
PNRP - Quanten- und theoretische Chemie
PNRA - Chemoinformatik
PN - Chemie
PDX - Geschichte der Naturwissenschaften
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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