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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Mikrobiologie Voltage-Gated Calcium Channels
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Beschreibung
This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they… interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calciumchannel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
10.11.2023
Sprache
Englisch
EAN
9783031088834
Herausgeber
Springer International Publishing
Sonderedition
Nein
Seitenanzahl
710
Einbandart
Broschiert
Schlagwörter
Activation, Biophysics, Peptide, cardiovascular, genes, distribution, physiology, regulation, the role of CA+2, Cyclic Nucleotide-Gated channels, P2X Receptors, Calcium channel discovery, Ca2+ Signaling and storage, calcium channel genes, epilepsy, hypertension
Thema-Inhalt
PSF - Zellbiologie (Zytologie)
PSAN - Neurowissenschaften
MFG - Physiologie
PHVN - Biophysik
MKG - Pharmakologie
Höhe
254 mm
Breite
17.8 cm
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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