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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Beyond the Dish: Unveiling DNA Repair Mechanisms in 3D Cell Culture Models
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Beyond the Dish: Unveiling DNA Repair Mechanisms in 3D Cell Culture Models
Parekh (Broschiert, Englisch)
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Beschreibung
Traditional cell culture methods, primarily utilizing flat, two-dimensional (2D) plastic dishes, have long been the cornerstone of biological research. However, these models often fail to accurately reflect the complexities of natural cellular environments. This limitation hinders our ability to fully understand fundamental cellular processes, including DNA repair. DNA, the blueprint of life, is… constantly under attack from various sources, such as ultraviolet radiation, free radicals, and mutagenic chemicals. Cells possess intricate DNA repair mechanisms to counteract this damage and maintain genomic integrity. However, studying these mechanisms in a dish often falls short due to the lack of three-dimensional (3D) architecture, cell-cell interactions, and physiological cues present in living tissues.
Limitations of 2D Cell Culture Models
2D cultures offer a simplified and controlled environment for studying cells. However, this very simplicity becomes a drawback when investigating DNA repair. Here's why:
•Lack of 3D architecture: Cells in their natural state reside in a 3D extracellular matrix (ECM) that provides structural support, biochemical cues, and influences cell behavior. Flat plastic dishes lack this crucial element, leading to altered cell morphology, gene expression, and ultimately, DNA repair efficiency. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
29.05.2024
Sprache
Englisch
EAN
9783384242242
Herausgeber
tredition
Sonderedition
Nein
Autor
Parekh
Seitenanzahl
78
Einbandart
Broschiert
Einbandart Details
Klebebindung
Schlagwörter
DNA Repair Mechanisms, 3D Cell Culture Models, Beyond Traditional Cell Culture, Mimicking Tissue Microenvironment, Unveiling Cellular Processes in 3D, DNA Damage Response Pathways, Advanced Cell Culture Techniques, Drug Discovery and DNA Repair, Therapeutic Targeting of Repair Defects, Cancer and DNA Repair Mechanisms
Thema-Inhalt
PSA - Biowissenschaften, allgemein
PSX - Humanbiologie
PST - Botanik und Pflanzenwissenschaften
PSF - Zellbiologie (Zytologie)
PSV - Zoologie und Tierwissenschaften
Höhe
234 mm
Breite
15.5 cm
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