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Atropisomerism in Asymmetric Organic Synthesis

(Gebundene Ausgabe, Englisch)

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Beschreibung
Unique overview of the recent synthetic methodologies of the atropisomeric molecules and their numerous practical applications Atropisomerism in Asymmetric Organic Synthesis: Challenges and Applications presents new methodologies, strategies, unique catalysts, and solutions to challenges in the area of oxidative heterocoupling. After a general introduction for the concept of atropisomerism, this book focuses on the recent advances in the atroposelective synthesis of axially chiral compounds and how these advances had a significant impact on several applications in asymmetric catalysis and the synthesis of natural products. The book covers the recent examples of metal-catalyzed (Cu, Fe, Ru, V, etc) and organocatalyzed atroposelective syntheses of axially chiral compounds using diverse approaches, including cross-coupling reactions, ring-opening reactions, formation of new aromatic rings, and desymmetrization via functional group transformation. The impact of these efficient strategies on various applications in asymmetric catalysis, total synthesis of natural products, synthesis of polycyclic heteroaromatics (PHAs), and the drug industry is also addressed. Edited by two highly qualified academics, Atropisomerism in Asymmetric Organic Synthesis explores sample topics including: * Iron- and ruthenium-catalyzed atroposelective synthesis of axially chiral compounds and the catalytic applications of multinuclear zinc complexes with axially chirality * Vanadium-catalyzed atroposelective coupling of arenols and application in the synthesis of polycyclic heteroaromatics PHAs * Mechanisms of atroposelective Suzuki-Miyaura coupling towards axially chiral biaryls and organocatalytic enantioselective formation of atropisomers * Synthesis of atropisomers via enantioselective ring-opening reactions and the impact of axially chiral ligands and catalysts derived from atropisomeric binaphthyl structures * Binaphthyl-based chiral DMAP derivatives in enantioselective transformations and catalytic atroposelective oxidative coupling in natural product synthesis Enabling readers to comprehensively understand the development history, research status, and potential of atropisomeric synthesis, Atropisomerism in Asymmetric Organic Synthesis is an essential, up-to-date reference for researchers and scientists in the field.
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Technische Daten


Erscheinungsdatum
04.12.2024
Sprache
Englisch
EAN
9783527352838
Herausgeber
Wiley-VCH
Sonderedition
Nein
Seitenanzahl
352
Auflage
1
Einbandart
Gebundene Ausgabe
Buch Untertitel
Challenges and Applications
Autorenporträt
Shinobu Takizawa is Associate Professor at the Institute of Scientific and Industrial Research (SANKEN) and AI Research Center at Osaka University (Japan). He received his Ph.D. in chemistry at the Graduate School of Pharmaceutical Science, Osaka University in 2000. From 2006 to 2008 he did postdoctoral studies at The Scripps Research Institute (USA) with Professor Dale L. Boger. He received the Daiichi Pharmaceutical Co. Ltd. Award in Synthetic Organic Chemistry, Japan (2000), the Pharmaceutical Society of Japan Award for Young Scientists (2009), the Daiichi-Sankyo Co. Ltd. Award in Synthetic Organic Chemistry, Japan (2009), the Osaka University Presidential Award for Encouragement in Research (2015) and the Pharmaceutical Society of Japan Award for Divisional Scientific Promotion (2019). His current research interest focuses on developing sustainable synthetic reactions with machine learning optimization. He is the author of more than 125 articles.
Schlagwörter
Chemie, Chemistry, Chiralität (Chemie), Homogene Katalyse, Homogeneous Catalysis, Methods - Synthesis & Techniques, Organische Chemie, Organische Chemie / Methoden, Synthesen, Verfahren, Pharmaceutical & Medicinal Chemistry, Pharmazeutische u. Medizinische Chemie
Thema-Inhalt
PNN - Organische Chemie
Höhe
244 mm
Breite
17 cm

Hersteller: Wiley-VCH GmbH, Boschstrasse 12, Weinheim, Deutschland, 69469, product_safety@wiley.com, Wiley-VCH GmbH

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