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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Medizin Allg. & Lexika Modern Survival Analysis in Clinical Research
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Modern Survival Analysis in Clinical Research
Ton J. Cleophas, Aeilko H. Zwinderman (Broschiert, Englisch)
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Beschreibung
An important novel menu for Survival Analysis entitled Accelerated Failure Time (AFT) models has been published by IBM (international Businesss Machines) in its SPSS statistical software update of 2023. Unlike the traditional Cox regressions that work with hazards, which are the ratio of deaths and non-deaths in a sample, it works with risk of death, which is the proportion of deaths in the same… sample. The latter approach may provide better sensitivity of testing, but has been seldom applied, because with computers risks are tricky and hazards because they are odds are fine. This was underscored in 1997 by Keiding and colleague statisticians from Copenhagen University who showed better-sensitive goodness of fit and null-hypothesis tests with AFT than with Cox survival tests. So far, a controlled study of a representative sample of clinical Kaplan Meier assessments, where the sensitivity of Cox regression is systematically tested against that of AFT modeling, hasnot been accomplished. This edition is the first textbook and tutorial of AFT modeling both for medical and healthcare students and for professionals. Each chapter can be studied as a standalone, and, using, real as well as hypothesized data, it tests the performance of the novel methodology against traditional Cox regressions. Step by step analyses of over 20 data files stored at Supplementary Files at Springer Interlink are included for self-assessment. We should add that the authors are well qualified in their field. Professor Zwinderman is past-president of the International Society of Biostatistics (2012-2015) and Professor Cleophas is past-president of the American College of Angiology (2000-2002). From their expertise they should be able to make adequate selections of modern data analysis methods for the benefit of physicians, students, and investigators. The authors have been working and publishing together for 25 years and their research can be characterized asa continued effort to demonstrate that clinical data analysis is not mathematics but rather a discipline at the interface of biology and mathematics. 90,94 €
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Technische Daten
Erscheinungsdatum
31.05.2024
Sprache
Englisch
EAN
9783031316340
Herausgeber
Springer International Publishing
Sonderedition
Nein
Autor
Ton J. Cleophas, Aeilko H. Zwinderman
Seitenanzahl
224
Auflage
1
Einbandart
Broschiert
Buch Untertitel
Cox Regressions Versus Accelerated Failure Time Models
Schlagwörter
Cox Regression, Clinical Medicine, Survival Analysis, Accelerated Failure Time Modeling, Statistical Data Analysis
Thema-Inhalt
MB - Medizin, allgemein
PBT - Wahrscheinlichkeitsrechnung und Statistik
Höhe
235 mm
Breite
15.5 cm
Transparenz & Sicherheit
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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