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Transfer von Δ9-Tetrahydrocannabinol (Δ9-THC) und anderen Cannabinoiden aus ‎nutzhanfhaltigen Futtermitteln in die Milch von Kühen

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Transfer von Δ9-Tetrahydrocannabinol (Δ9-THC) und anderen Cannabinoiden aus ‎nutzhanfhaltigen Futtermitteln in die Milch von Kühen

Bettina Wagner (Broschiert, Deutsch)

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"Transfer of Δ9-tetrahydrocannabinol (Δ9-THC) and other cannabinoids from feed containing industrial hemp ‎into the milk of cows" Interest in the use of industrial hemp (legally cultivable hemp with a maximum tetrahydrocannabinol content ‎of 0.3%) is growing, and in recent years many novel hemp products have been launched - including animal ‎feed. Industrial hemp contains cannabinoids. Some of these have psychoactive effects in humans and animals ‎‎(e.g., Δ9-tetrahydrocannabinol, Δ9-THC) or other pharmacological effects (e.g., cannabidiol, CBD). So far, it ‎was unclear to what extent these cannabinoids are transferred from feed containing industrial hemp into ‎products of animal origin and whether this poses a risk to the consumer. ‎ In the present study, "Transfer of Δ9-tetrahydrocannabinol (Δ9-THC) and other cannabinoids from feed ‎containing industrial hemp into the milk of cows", the results of a feeding trial with industrial hemp silage in ‎ten lactating dairy cows are presented. Initially, part of the corn silage in the animals' feed ration was replaced ‎for seven days by industrial hemp silage made from the entire hemp plant (GP-silage, very low cannabinoid ‎concentration). This was followed by six days of partial replacement of corn silage with industrial hemp silage ‎consisting only of leaves, inflorescences and seeds of the plant (BBS silage, higher cannabinoid concentration). ‎Feeding was done in two dosages (group 1: low industrial hemp content; group 2: high industrial hemp ‎content). During the experiment, milk and blood samples were obtained and the vital parameters and behavior ‎of the cows were recorded. Analysis was performed by a liquid chromatography-tandem mass spectrometry-‎based method (HPLC-MS/MS), which allowed differentiation between psychoactive Δ9-THC and its non-‎psychoactive precursor Δ9-tetrahydrocannabinolic acid (Δ9-THCA). Transfer rates of 0.24 ± 0.04% and 0.15 ± 0.05% from feed to milk were calculated for Δ9-THC and CBD, ‎respectively. In different exposure scenarios calculated using the EFSA-RACE tool, several consumer groups ‎exceeded the acute reference dose (ARfD) for Δ9-THC when milk and dairy products were consumed and ‎industrial hemp silage was used to feed dairy cows. The exceedance was most pronounced in children when ‎BBS-silage was used. In terms of animal health, feeding the low-cannabinoid GP-silage resulted in no ‎significant effects in cows, whereas feeding the high-cannabinoid BBS-silage resulted in significant reductions ‎in heart and respiratory rates, impaired movement coordination, reddened eyes, nasal secretion, ‎hypersalivation, and pronounced tongue play.‎ Weniger zeigen

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Produktinformationen

Technische Daten

Erscheinungsdatum

26.08.2024

Sprache

Deutsch

EAN

9783967292428

Herausgeber

Mensch & Buch

Sonderedition

Nein

Autor

Bettina Wagner

Seitenanzahl

160

Auflage

Einbandart

Broschiert

Einbandart Details

Klebebindung

Warnhinweise und Sicherheitsinformationen

Informationen nach EU Data Act

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