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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Biologie Biochemie & Biophysik Biodegradable Long Acting Injectables and Implants
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Biodegradable Long Acting Injectables and Implants
(Gebundene Ausgabe, Englisch)
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Beschreibung
Long acting injectables and implants (LAI) are known to improve patient adherence and treatment outcomes. They reduce costs for the healthcare system and ensure sustainable sales for pharmaceutical companies. LAI are usually administered intramuscularly (IM) or subcutaneously (SC). In this way, the drug is released from its depot in a controlled manner over a longer period of time (e.g., a few… days to a year). There is a trend toward increasing interest in the development of long-acting drugs for local administration versus systemic administration of depot products (i.e., IM or SC injection). This is leading to finding new ways of administration of the depot formulation, intra-ocular, intra-articular, pri-tendon etc. Therefore, it is expected that more drugs based on LAI formulations will enter the clinical phase in the future. Due to many benefits in adherence, efficacy, and safety of the treatment up until now around 50 brand name medicines using different biodegradable long-acting technology have received FDA approval. Manufacturing of LAI involves many steps with their unique challenges, which is why pharmaceutical companies consider them to be complex formulations to develop. Most of the published papers and books in this field are written by scientists who never worked in industry and whose knowledge on the topic is limited to small scale formulation screening. Therefore, this book aims to address the challenges of the development of biodegradable LAI from an industrial perspective. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
30.03.2025
Sprache
Englisch
EAN
9783031723018
Herausgeber
Springer International Publishing
Sonderedition
Nein
Seitenanzahl
256
Einbandart
Gebundene Ausgabe
Buch Untertitel
An Industry View
Schlagwörter
oil solution, PLGA microparticles, microcrystal suspensions, preformed and in situ forming implants, controlled release, sustained release, long acting injectables, microspheres, extended release, local drug delivery, implants
Thema-Inhalt
PNB - Medizinische Chemie, Pharmazeutische Chemie
MBGR - Medizinische Forschung
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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