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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Chemie Theoretische Chemie Applications of Mass Spectrometry in Life Safety
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Applications of Mass Spectrometry in Life Safety
(Broschiert, Englisch)
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Beschreibung
Mass spectrometry (MS) along with its hyphenated techniques is capable of high throughput, sensitivity, accuracy and selectivity for the analysis of structure and composition of almost any product. Like in electrophoresis, MS separates mo- cules based on the mass-to-charge ratio. In case of gel electrophoresis (SDS- PAGE), a well-known and efficient bioanalytical technique, proteins bear negative… charges but have the same charge density, so proteins are separated according to their size. Similarly, in case of MS analysis, proteins carry the same charge, and are separated by their molecular weight. Unlike SDS-PAGE, however, modern ultra high resolution MS discerns very small mass differences and can resolve and completely identify in a single experiment species of the same nominal mass in complex biological mixtures. Consequently, MS can be used for the structural characterization, identification and sensitive detection of mixtures of biomolecules or for assessing the quality of isolated proteins (purity, integrity, or post-translational modifications, for example), carbohydrates, nucleic acids, drugs, metabolites, pollutants etc. In the post-genome era, MS is continuously developing as one of the most re- able analytical method for elucidating the structure of molecules originating from various biological matrices. The potential of MS for high-sensitive structural a- lyses became unsurpassable after the introduction of electrospray (ESI) and matrix assisted laser/desorption ionization (MALDI) methods, on one hand, and the pos- bility to deduce in detail unknown biopolymer structures by highly accurate mo- cular mass measurement followed by sequencing using dissociation techniques based on multiple stage MS, on the other. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
15.08.2008
Sprache
Englisch
EAN
9781402088100
Herausgeber
Springer Netherland
Serien- oder Bandtitel
NATO Science for Peace and Security Series A: Chemistry and Biology
Sonderedition
Nein
Seitenanzahl
238
Auflage
1
Einbandart
Broschiert
Schlagwörter
Biology, Chemistry, Disaccharid, Mass Spectrometry, NATO, Oligosaccharid, Peace, Proteomics, Science, Security, Sub-Series A, proteins
Thema-Inhalt
PNFS - Spektroskopie, Spektrochemie, Massenspektrometrie
PSB - Biochemie
PSA - Biowissenschaften, allgemein
PNF - Analytische Chemie
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH
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