Bis zu 50 % günstiger als neu 3 Jahre rebuy Garantie Professionelles Refurbishment

Pharmacokinetic Profiling in Drug Research

Handgeprüfte Gebrauchtware

Bis zu 50 % günstiger als neu

Der Umwelt zuliebe

Nur 4,24 € und

Gratisversand mit dem 15 % Rabattcode

Pharmacokinetic Profiling in Drug Research

Bernard Testa, Stefanie D. Krämer, Heidi Wunderli-Allenspach, Gerd Folkers (Gebundene Ausgabe, Deutsch)

Keine Bewertungen vorhanden

Optischer Zustand

Sehr guter Zustand: leichte Gebrauchsspuren vorhanden
z.B. mit vereinzelten Knicken, Markierungen oder mit Gebrauchsspuren am Cover
Gut als Geschenk geeignet

Beschreibung

Informatics and robotics are the workhorses of a technological revolution in drug research. On them are based combinatorial chemistry, which yields compounds by the many thousands, and high-throughput bioassays, which screen them for activity. The results are avalanches of 'hits', which invade the databases like swarms of locusts. But far from being a plague, these innumerable compounds become a blessing if properly screened for 'drugability', i.e., for 'drug-like' properties such as good pharmacokinetic (PK) behavior. Pharmacokinetic profiling of bioactive compounds has, thus, become a sine qua non condition for cherry-picking the most promising hits. Just as important, but less visible, are the structure-property and structure-ADME relations, which emerge from PK profiling and provide useful feedback when designing new synthetic series. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming development and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, powerful biological, physicochemical, and computational approaches are being developed, whose objectives are to increase the clinical relevance of drug design and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. The profiling of ADME properties (absorption, distribution, metabolism, and excretion) is the topic of this book. Following the extraordinary success of the previous work ('Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies', Eds. B. Testa, H. van de Waterbeemd, G. Volkers, R. Guy, Verlag Helvetica Chimica Acta, Zürich, 2001, 655 pages), there was a need for an essentially new edition focusing on the latest theoretical and technological breakthroughs. In this unique work, international authorities and practicing experts from academia and industry offer state-of-the-art presentations of concepts, methods and technologies now in use or development in drug research. The biological strategies emphasized in the book include cell cultures, drug-metabolizing enzymes, transporters and plasma protein binding. The physicochemical strategies focus on artificial membrane-permeability assays, on solubility and lipophilicity and related molecular properties as factors and predictors of pharmacokinetic behavior, and on stability and solid-state properties. Computational strategies comprize the exploration of property spaces, pharmacophore searching to predict biotransformation and enzyme inhibition, and expert systems to process biopharmaceutical profiling data. In addition to its 28 chapters, the book includes a CD-ROM containing the invited lectures, oral communications, and posters (in full version) presented at the Third LogP Symposium, 'Physicochemical and Biological Profiling in Drug Research', held at the Federal Institute of Technology (ETH) of Zürich in March 2004. Weniger zeigen

4,99 €

Gebundene Ausgabe | Sehr gut

Nur 4,24 € und

Gratisversand mit dem 15 % Rabattcode

Nur noch 1 verfügbar!

Versandbereit in 3-4 Werktagen

zzgl.

Nur noch 1 verfügbar!

Versandbereit in 3-4 Werktagen

zzgl.

Handgeprüfte Gebrauchtware

Bis zu 50 % günstiger als neu

Der Umwelt zuliebe

Produktinformationen

Technische Daten

Erscheinungsdatum

13.01.2006

Sprache

Deutsch

EAN

9783906390352

Herausgeber

Helvetica Chimica Acta

Sonderedition

Nein

Autor

Bernard Testa, Stefanie D. Krämer, Heidi Wunderli-Allenspach, Gerd Folkers

Seitenanzahl

500

Auflage

Einbandart

Gebundene Ausgabe

Buch Untertitel

Biological, Physicochemical, and Computational Strategies

Schlagwörter

Chemie, Chemistry, Pharmaceutical & Medicinal Chemistry, Pharmakokinetik, Pharmazeutische Chemie, Pharmazeutische u. Medizinische Chemie

Thema-Inhalt

PNB - Medizinische Chemie, Pharmazeutische Chemie

Höhe

246 mm

Breite

18 cm

Warnhinweise und Sicherheitsinformationen

Informationen nach EU Data Act

Bewertungen

-.-

Leider noch keine Bewertungen

Sicher bei rebuy kaufen

Sehr Gut, 4.52/5.00

Aus 200.000+ Bewertungen

Schreib die erste Bewertung für dieses Produkt!

Wenn du eine Bewertung für dieses Produkt schreibst, hilfst du allen Kund:innen, die noch überlegen, ob sie das Produkt kaufen wollen. Vielen Dank, dass du mitmachst!