The Molecular Biology of Cancer. A Bridge from Bench to Bedside

Englisch

9781118008812

John Wiley & Sons

632

2

Taschenbuch

Contributors, vii Preface to the Second Edition, ix Reviews of the First Edition, x Acknowledgments and Dedication, xi About the Companion Website, xii Introduction, 1 1 Overview of Cancer Biology, 3 Michael Khan and Stella Pelengaris 2 The Burden of Cancer, 43 William P. Steward and Anne L. Thomas 3 Nature and Nurture in Oncogenesis, 67 Michael Khan and Stella Pelengaris 4 DNA Replication and the Cell Cycle, 111 Stella Pelengaris and Michael Khan 5 Growth Signaling Pathways and the New Era of Targeted Treatment of Cancer, 146 Stella Pelengaris and Michael Khan 6 Oncogenes, 188 Stella Pelengaris and Michael Khan 7 Tumor Suppressors, 239 Martine F. Roussel 8 Cell Death, 266 Stella Pelengaris and Michael Khan 9 Senescence, Telomeres, and Cancer Stem Cells, 295 Maria A. Blasco and Michael Khan 10 Genetic Instability, Chromosomes, and Repair, 314 Michael Khan 11 There Is More to Cancer than Genetics: Regulation of Gene and Protein Expression by Epigenetic Factors, Small Regulatory RNAs, and Protein Stability, 350 Stella Pelengaris and Michael Khan 12 Cell Adhesion in Cancer, 383 Charles H. Streuli 13 Tumor Immunity and Immunotherapy, 410 Cassian Yee 14 Tumor Angiogenesis, 429 Christiana Ruhrberg 15 Cancer Chemistry: Designing New Drugs for Cancer Treatment, 438 Ana M. Pizarro and Peter J. Sadler 16 Biologically Targeted Agents from Bench to Bedside, 461 Michael Khan, Peter Sadler, Ana M. Pizarro, and Stella Pelengaris 17 The Diagnosis of Cancer, 509 Anne L. Thomas, Bruno Morgan, and William P. Steward 18 Treatment of Cancer: Chemotherapy and Radiotherapy, 526 Anne L. Thomas, J.P. Sage, and William P. Steward 19 Caring for the Cancer Patient, 544 Nicky Rudd and Esther Waterhouse 20 Systems Biology of Cancer, 554 Walter Schubert, Norbert C.J. de Wit, and Peter Walden Glossary, 585 Answers to Questions, 597 Index, 603

273 mm

21.9 cm