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Der Umwelt zuliebe

Antibodies

(Gebundene Ausgabe, Englisch)

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Beschreibung
It is now over one hundred years since von Behring and Kitsato first concluded experiments that led to the use of passive immunisation, employing antibodies raised in animals against tetanus and diphtheria toxins. The advancement of technology both in manufacturing purity product in a cost effective way and the clinical research has proved that antibodies are one ofthe most successful products in biotechnology. Monoclonal antibodies account for between one-third and one-halfof all pharmaceutical products in development and human clinical trials. Both the nature of monoclonal antibody therapies and the relatively large size of the monoclonal antibody dictate the production requirements, for many ofthese therapeutics the monoclonal antibody product will be 100 kilogrammes or more per year. It is widely acknowledged that there is currently a worldwide shortage of biomanufacturing capacity, and the active pharmaceutical ingredient material requirements for these products are expected to increase. Thus the industry is looking for new sources and extensive studies are being carried out not only for alternative technology to meet the needs but also to reveal the new therapeutic applicationsofantibodies. This book brings to the forefront current advances in novel technologies for the manufacturing of monoclonal antibodies and also their extensive clinical importance. The first four chapters give an overview of the new technologies and the successful application in the manufacture of monoclonal antibodies with clinical purity. The next chapters address the application of antibodies in cancer therapy and functional genomic therapy.
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Technische Daten


Erscheinungsdatum
31.03.2004
Sprache
Englisch
EAN
9780306483158
Herausgeber
Springer US
Sonderedition
Nein
Seitenanzahl
232
Auflage
1
Einbandart
Gebundene Ausgabe
Buch Untertitel
Volume 2: Novel Technologies and Therapeutic Use
Schlagwörter
HIV, cancer, cancer therapy, cells, development, future, immunotherapy, kinetics, macrophages, manufacturing, pharmaceutical, pharmacokinetics, research, safety, tissue
Thema-Inhalt
MQP - Pharmazie, Apotheke MJCM - Immunologie MKG - Pharmakologie MQW - Biomedizinische Technik
Inhaltsverzeichnis
Volume 1:- 1. Concepts in Development of Manufacturing Strategies for Monoclonal Antibodies; B. Fish. 2. Antibody Fragments: Production, Purification and Formatting for Therapeutic Applications; D.J. Glover, D.P. Humphreys. 3. Large Scale Production of Therapeutic Antibodies: Considerations for Optimizing Product Capture and Purification; G. Kemp, P. O'Neil. 4. Scale-Up of Antibody Purification. From Laboratory Scale to Production; L.R. Jacob, M. Frech. 5. Purification of Antibody by Chromatographic Methods; C. Vandevyver, R. Freitag. 6. Quality Control of Antibodies for Human Use; A. Richter, M. Jostameling, K. Müller, A. Herrmann, M. Pitschke. 7. Expression of Human Anti Rh(D) Monoclonal Antibodies into Different Cell lines: Influence on their Functional Properties; C. de Romeuf, C. Gaucher, A. Glacet, S. Jorieux, P. Klein, D. Bourel. 8. Monoclonal Antibody Production: Minimising Virus Safety Issues; J. Bray, M.K. Brattle. 9. Contract Manufacturing of Biopharmaceutical Grade Antibodies; L.A. Van Der Pol, D.F. Westra. 10. The Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies; D.B. Haughey, P.M. Jardieu. 11. Regulatory and Legal Requirements for the Manufacture of Antibodies; L. Tsang. Index. Volume 2:- 1. Transgenic technology for monoclonal antibody production; S. Sensoli. 2. Generation, engineering and production of human antibodies using HuCAL; R. Ostendorp, C. Frisch, M. Urban. 3. Achieving appropriate glycosylation during the scaleup of antibody production; X.K. Deng, T. Shantha Raju,K.J. Morrow Jr. 4. Approaches to devise antibody purification processes by chromatography; E. Boschetti. 5. Novel HIV neutralizing antibodies selected from phage display libraries; M. Moulard, Mei-Yun Zhang, D.S. Dimitrov. 6. Monoclonal and bispecific antibodies in combination with radiotherapy for cancer treatment; D. Azria, C. Larbouret, B. Robert, M. Ozsahin, J.B. Dubois, A. Pèlegrin. 7. Antibodies, a potent tool to target genes into designated cells and tissues; F. Hirsch, O. Deas, G. Carvalho, A. Dürrbach, D. Thierry, A. Chapel. 8. Intrabodies: development and application in functional genomics and therapy; A. Barberis, A. Auf Der Maur, K. Tissot, P. Lichtlen. 9. Expression of recombinant antibodies by tumour cells: on road to anti-tumour therapy; E. Bonnin, J.-L. Teillaud. 10. Antitumor antibodies: from research to clinic; S. Ménard, S.M. Pupa, M. Campiglio, E. Tagliabue. 11. Macrophages for immunotherapy; D. Loirat, S. Jacod, A. Boyer, F. Auzelle, A. McAllister, J.-P. Abstado, J. Bartholeyns, D. Prigent. 12. Future prospects in antibody engineering and therapy; S. Siberil, J.-L. Teillaud. Index.
Höhe
235 mm
Breite
15.5 cm

Transparenz & Sicherheit

Hersteller: Humana, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com, Springer Nature Customer Service Center GmbH

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